92-54-6

Basic information

• Product Name: 1-Phenylpiperazine
• Synonyms: TIMTEC-BB SBB003943;N-PHENYLPIPERAZINE;LABOTEST-BB LTBB000705;AKOS BBS-00003581;1-PHENYLPIPERAZINE;1-Fenylpiperazin;Phenylpiperazine;1-Phenylpiperazine 97
• CAS NO: 92-54-6
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• EINECS: 202-165-6
• Product Categories: Piperaizine;API intermediates;(intermediate of levodropropizine);Piperazines;Bioactive Small Molecules;Building Blocks;C10;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;P
• Mol File: 92-54-6.mol
• Article Data: 58

Chemical Properties

• Melting Point: 18.8 °C
• Boiling Point: 286 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.062 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00252mmHg at 25°C
• Refractive Index: n20/D 1.588(lit.)
• Storage Temp.: Store in dark!
• Solubility: Insoluble
• PKA: pK1:8.71(+1) (25°C,μ=0.1)
• Water Solubility: Insoluble
• BRN: 132157
• CAS DataBase Reference: 1-Phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenylpiperazine(92-54-6)
• EPA Substance Registry System: 1-Phenylpiperazine(92-54-6)

Safety Data

• Hazard Codes: T,C
• Statements: 22-24-34-36/37/38-23/24/25
• Safety Statements: 26-36/37/39-45-28A
• RIDADR: UN 2922 8/PG 2
• WGK Germany: 3
• RTECS: TM2625000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 92-54-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Safety Profile

Poison by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Combustible when exposed to heat or flame. It supports combustion and decomposes to yield toxic fumes of NOx. To fight fire, use water, foam, dry chemical. See also PIPERAZINE

InChI:InChI=1/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2/p+1

Upstream product

• 10024-89-2 morpholin hydrochloride 
• 142-04-1 aniline hydrochloride 
• 110-85-0 piperazine 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 
• 62-53-3 aniline 
• 77278-63-8 4-phenyl-piperazine-1-carboxylic acid tert-butyl ester 
• 222038-81-5 1-methanesulfonyl-4-phenyl-piperazine 
• 108-90-7 chlorobenzene 
• 21057-43-2 1-allyl-4-phenyl-piperazine 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 13716-12-6 tri-tert-butyl phosphine 

Downstream Products

• 66307-43-5 1-phenoxy-3-(4-phenyl-piperazin-1-yl)-propan-2-ol 
• 41103-45-1 1-(4-phenyl-piperazin-1-yl)-propan-2-ol 
• 127331-76-4 α-(2-phenoxyethyl)-4-phenyl-1-piperazineethanol 
• 145248-19-7 3-(4-bromophenyl)-2-hydroxy-1-[1-(4-phenylpiperazinyl)]propane 
• 101512-13-4 2-(4-Phenyl-piperazin-1-yl)-nicotinamide 
• 83823-52-3 1-Chroman-3-yl-4-phenyl-piperazine 
• 90125-85-2 1-Phenyl-4-(2-pyridin-2-yl-ethyl)-piperazine; compound with (Z)-but-2-enedioic acid 
• 34658-18-9 3-ethoxy-7-(4-phenyl-piperazin-1-yl)-2,3-dihydro-thiazolo[3,2-a]pyrimidin-5-one 
• 73841-59-5 3-methyl-4-(4-phenyl-piperazin-1-ylmethyl)-2H-isoxazol-5-one 
• 69560-86-7 4-methyl-7-[4-(4-phenyl-piperazin-1-ylmethyl)-5-thioxo-4,5-dihydro-[1,3,4]oxadiazol-2-ylmethoxy]-chromen-2-one 
• 68936-32-3 1-(benzo[d]isoxazol-3-yl-methanesulfonyl)-4-phenyl-piperazine 
• 40678-98-6 1-phenyl-4-[3-(2-pyridin-2-yl-[1,3]dioxolan-2-yl)-propyl]-piperazine 
• 40678-94-2 1-phenyl-4-[3-(2-pyridin-3-yl-[1,3]dioxolan-2-yl)-propyl]-piperazine 
• 69962-99-8 1-phenyl-4-[3-(2-pyridin-4-yl-[1,3]dioxolan-2-yl)-propyl]-piperazine 

Relevant articles and documents

Eco-friendly synthesis of ionic helical polymers and their chemical properties and reactivity

Reaction of N-(2,4-dinitrophenyl)pyridinium chloride (salt(Cl-)) with sodium dicyanamide (Na(CN)2N) resulted in anion exchange between Cl- and (CN)2N- to yield a new Zincke salt, salt((CN)2N-). Reactions of salt((CN)2N-) with piperazine, specifically (R)-(-)- or (S)-(+)-2-methylpiperazine under eco-friendly conditions, such as in aqueous solution, in the absence of a catalyst, and at room temperature, resulted in pyridinium ring opening to yield ionic high-molecular-weight polymers with 5-2,4-dienylideneammonium dicyanamide units or chiral 5-(2-methylpiperazinium)-2,4-dienylideneammonium dicyanamide units, namely, polymer(H;(CN)2N-), polymer(R-Me;(CN)2N-), and polymer(S-Me;(CN)2N-). UV-Vis measurements revealed that the π-conjugation system expanded along the polymer chain due to the orbital interaction between the electrons on the two nitrogen atoms of the piperazinium ring. Circular dichroism (CD) measurements revealed a helical conformation of the main chain in polymer(R-Me;(CN)2N-) and polymer(S-Me;(CN)2N-). The reaction of polymer(H;(CN)2N-) with p-phenylenediamine (PDA) caused recyclization of the 2,4-dienylideneammonium unit and resulted in depolymerization to yield N-(4-aminophenyl)pyridinium dicyanamide. Cyclic voltammetry analysis suggested that the polymers obtained in this study undergo electrochemical oxidation and reduction.

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.