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CAS

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134486-00-3

FMOC-3-IODO-L-TYROSINE, also known as N-(9-fluorenylmethoxycarbonyl)-3-iodo-L-tyrosine, is a synthetic amino acid derivative with a unique chemical structure. It is characterized by its white to off-white powder form and is widely utilized in various applications due to its specific properties.

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  • 134486-00-3 Structure

  • Basic information

    1. Product Name: FMOC-3-IODO-L-TYROSINE
    2. Synonyms: 3-(4-HYDROXY-3-IODOPHENYL)-2-FLUORENYLMETHOXYCARBONYLAMINOPROPIONIC ACID;(9-FLUORENYLMETHOXYCARBONYL)-3-IODO-L-TYROSINE;FMOC-TYR(3-I)-OH;FMOC-PHE(4-HYDROXY, 3-I)-OH;FMOC-3-IODO-L-TYROSINE;FMOC-3-IODO-TYR-OH;FMOC-3-IODO-TYROSINE;FMOC-3-I-PHE(4-OH)-OH
    3. CAS NO:134486-00-3
    4. Molecular Formula: C24H20INO5
    5. Molecular Weight: 529.32
    6. EINECS: N/A
    7. Product Categories: Amino Acid Derivatives;Amino Acids
    8. Mol File: 134486-00-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 675.7±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.634±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: DMF (Slightly), Methanol (Slightly)
    9. PKA: 2.86±0.10(Predicted)
    10. CAS DataBase Reference: FMOC-3-IODO-L-TYROSINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: FMOC-3-IODO-L-TYROSINE(134486-00-3)
    12. EPA Substance Registry System: FMOC-3-IODO-L-TYROSINE(134486-00-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 134486-00-3(Hazardous Substances Data)

134486-00-3 Usage

Uses

Used in Pharmaceutical Industry:
FMOC-3-IODO-L-TYROSINE is used as a reagent for the synthesis of antitumor compounds, such as rubiyunnanin B dityrosine core, through Suzuki coupling. This application is significant because it contributes to the development of novel and effective anti-cancer drugs, potentially improving the treatment options for patients suffering from various types of cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 134486-00-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,4,8 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 134486-00:
(8*1)+(7*3)+(6*4)+(5*4)+(4*8)+(3*6)+(2*0)+(1*0)=123
123 % 10 = 3
So 134486-00-3 is a valid CAS Registry Number.

134486-00-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-3-iodophenyl)propanoic acid

1.2 Other means of identification

Product number -
Other names Fmoc-3-iodo-L-tyrosine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134486-00-3 SDS

134486-00-3Downstream Products

134486-00-3Relevant articles and documents

Control of the iodination reaction on activated aromatic residues in peptides

Espuna, Gemma,Arsequell, Gemma,Valencia, Gregorio,Barluenga, Jose,Perez, Marta,Gonzalez, Jose M.

, p. 1307 - 1308 (2000)

By using a slight molar excess of the IPy2BF4 reagent in an acid containing medium, activated aromatic residues on Tyr derivatives and peptides selectively react yielding, as major products, the monoiododerivatives; this level of reaction control cannot be achieved by other iodinating methods.

Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells

Moore, Sandra Blaj,Van Der Hoek, Joost,De Capua, Antonia,Van Koetsveld, Peter M.,Hofland, Leo J.,Lamberts, Steven W. J.,Goodman, Murray,Taulane, Joseph P.

, p. 6643 - 6652 (2007/10/03)

Inhibition of growth hormone (GH) and prolactin (PRL) release from the anterior pituitary gland is mediated through somatostatin receptor subtypes sst2 and sst5. It has been found that somatostatin (SS) analogues that are selective for both receptor subty

SOMATOSTATIN ANALOGS WITH INHIBITORY ACTIVITY TO GROWTH HORMONE RELEASE

-

Page/Page column 24-25, (2008/06/13)

Provided are therapeutic and diagnostic somatostatin analogs including radiotherapeutic and radiodiagnostic reagents, and methods of making and use thereof.

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