cas 134579-47-8, 2-IODO-ISONICOTINIC ACID METHYL ESTER | Articles data ｜lookchem

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134579-47-8

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Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates
Efficient copper-catalyzed trifluoromethylation of aromatic iodides was achieved with TMSCF3 in the presence of trimethylborate. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decomposition. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionalization of different aromatic and heteroaromatic iodides.
Gonda, Zsombor,Kovacs, Szabolcs,Weber, Csaba,Gati, Tamas,Meszaros, Attila,Kotschy, Andras,Novak, Zoltan
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p. 4268 - 4271
(2014/09/30)

Aryl-4-ethynyl-isoxazole derivatives
The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula I wherein R1 to R5 are as described in the specification and pharmaceutically acceptable salt thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites, being useful as a cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
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Page/Page column 9

(2008/06/13)

Imidazole derivatives
Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating neuronal activity and plasticity which makes them key players in mediating processes underlying development of CNS as well as learning and memory formation. These compounds are useful in the control or treatment of diseases mediated by this receptor.
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(2008/06/13)

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588702-68-5
2-trifluoromethyl-isonicotinic acid methyl ester

Chemical Properties

Boiling Point: 305.6 °C at 760 mmHg
Flash Point:138.6 °C
Density: 1.844 g/cm³
Storage Temp.:Refrigerated.
Vapor Pressure: 0.000812mmHg at 25°C
Refractive Index: 1.603
PSA: 39.19000
LogP: 1.47280

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