- The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil
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A radical based direct C-H iodination protocol for quinolines, quinolones, pyridones, pyridines, and uracil has been developed. The iodination occurs in a C3 selective manner for quinolines and quinolones. Pyridones and pyridines undergo C3 and C5 iodination, while dimethyl uracil undergoes C5 iodination. Scope of the method was demonstrated through the rapid synthesis of both electron rich as well as electron poor heteroaromatic iodides. The protocol was found to be scalable and general, while a mechanism has been proposed.
- Dutta, Uttam,Deb, Arghya,Lupton, David W.,Maiti, Debabrata
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supporting information
p. 17744 - 17747
(2015/12/18)
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- Total Synthesis of Isodesmosine by Stepwise, Regioselective Negishi and Sonogashira Cross-Coupling Reactions
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Isodesmosine is a crosslinking pyridinium amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this paper, we describe the total synthesis of isodesmosine. The key features of this synt
- Koseki, Yohei,Sugimura, Takanori,Ogawa, Keita,Suzuki, Rina,Yamada, Haruka,Suzuki, Noriyuki,Masuyama, Yoshiro,Lin, Yong Y.,Usuki, Toyonobu
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p. 4024 - 4032
(2015/06/30)
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- Halogenation of pyridinols using bis(sym-collidine)iodine(I) and bis(sym-collidine)bromine(I) hexafluorophosphate
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Iodination and bromination of pyridinols was achieved by action of the title reagents in methylene chloride.
- Rousseau, Gerard,Robin, Sylvie
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p. 2467 - 2470
(2007/10/03)
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