13484-40-7

Basic information

• Product Name: 1-(2-Methoxyethyl)piperazine
• Synonyms: 1-(2-METHOXYETHYL)PIPERAZINE;RARECHEM AH CK 0124;Methoxyethylpiperazine;1-(2-Methoxyethyl)piperazine 98%;1-(2-METHOXYETHYL)-PIPERAZINE >98%;1-(2-Methoxyethyl)piperzazine;1-Methoxy-2-(piperazin-1-yl)ethane;1-(2-Methoxyethyl)piperazine, 98% 5GR
• CAS NO: 13484-40-7
• Molecular Formula: C7H16N2O
• Molecular Weight: 144.21
• EINECS: 1533716-785-6
• Product Categories: Amines and Anilines;Heterocycles;Building Blocks;Heterocyclic Building Blocks;Piperazines;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 13484-40-7.mol

Chemical Properties

• Melting Point: 100-101 °C
• Boiling Point: 193-194 °C(lit.)
• Flash Point: 188 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.970 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.333mmHg at 25°C
• Refractive Index: n20/D 1.4730(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.15±0.10(Predicted)
• BRN: 105098
• CAS DataBase Reference: 1-(2-Methoxyethyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methoxyethyl)piperazine(13484-40-7)
• EPA Substance Registry System: 1-(2-Methoxyethyl)piperazine(13484-40-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45-37/39
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• F: 10-34
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 13484-40-7(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
1-(2-Methoxyethyl)piperazine is used as a reactant for the preparation of biologically and pharmacologically active molecules. Its versatile chemical structure allows it to be a key component in the synthesis of various drugs and therapeutic agents.
2. Used in Chemical Research:
As a clear colorless to yellow liquid, 1-(2-Methoxyethyl)piperazine serves as a valuable reactant in chemical research and development. It can be utilized in the creation of new compounds with potential applications in various fields, including medicine, agriculture, and materials science.
3. Used in Drug Synthesis:
1-(2-Methoxyethyl)piperazine is used as a reactant in the synthesis of drugs, particularly those targeting the central nervous system. Its unique structure enables the development of molecules with specific pharmacological properties, making it a valuable asset in the pharmaceutical industry.

InChI:InChI=1/C7H16N2O/c1-10-7-6-9-4-2-8-3-5-9/h8H,2-7H2,1H3/p+2

Upstream product

• 100861-64-1 1-benzyl-4-(2-methoxy-ethyl)-piperazine 
• 110-85-0 piperazine 
• 627-42-9 2-chloroethyl methyl ether 
• 6482-24-2 2-Bromoethyl methyl ether 
• 88708-34-3 1-ethoxycarbonyl-4-(2-methoxyethyl)piperazine 
• 741287-48-9 tert-butyl 4-(2-methoxyethyl)piperazine-1-carboxylate 

Downstream Products

• 91663-65-9 2-Bromo-4-(2-chlorophenyl)-9-<4-(2-methoxyethyl)piperazino>-6H-thieno<3,2-f>-1,2,4-triazolo<4,3-a>-1,4-diazepine 
• 88701-67-1 8-chloro-1-<4-(2-methoxyethyl)piperazino>-6-phenyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 88701-69-3 8-chloro-6-(2-chlorophenyl)-1-<4-(2-methoxyethyl)piperazino>-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 112446-39-6 1-{1-[5-Chloro-2-(3,4-dichloro-phenylsulfanyl)-phenyl]-ethyl}-4-(2-methoxy-ethyl)-piperazine 
• 54147-48-7 4-(2-methoxy-ethyl)-piperazine-1-carbothioic acid amide 
• 904896-22-6 4-[4-(2-methoxyethyl)piperazin-1-yl]-2-nitrobenzaldehyde 
• 860343-99-3 4-{2-[4-(2-methoxy-ethyl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid 
• 849532-11-2 1-(4-bromo-benzene-sulfonyl)-4-(2-methoxy-ethyl)piperazine 

Relevant articles and documents

N - alkylpiperazine purification of

PROBLEM TO BE SOLVED: To provide a purification method of N-alkyl piperazines, capable of providing high purity N-alkyl piperazines with low cost and having a high recovery rate.SOLUTION: A mixture of N-alkyl piperazines and a piperazine is distilled in the presence of a polar organic solvent having a higher boiling point than that of the piperazine.

Method for producing N-alkylpiperazine

PROBLEM TO BE SOLVED: To provide a method for producing N-alkyl piperazines in high yield by selectively alkylating one amino group.SOLUTION: In the method for producing N-alkyl piperazines, piperazines represented by general formula (1) are reacted with a specific alkylating agent in the presence of an acid. In the formula: R-Rare each independently a hydrogen atom, a methyl group, an ethyl group, a 3-8C linear alkyl group or the like, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group, a methoxy group, an ethoxy group, a phenyl group, a benzyl group, a 2-phenylethyl group, or the like.

2,5-Disubstituted pyridines as potent GPR119 agonists

A series of 2-piperazinyl-5-alkoxypyridines were synthesized and screened against human GPR119 receptor. Through SAR analysis, compounds containing 2-alkylsulfonylpiperazinyl-5-alkoxypyridines were discovered and found to be potent agonists of the human GPR119 receptor.

Discovery and biological evaluation of adamantyl amide 11β-HSD1 inhibitors

A series of adamantyl amide 11β-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11β-HSD1 over 11β-HSD2 and possess excellent cellular potency in human and murine 11β-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.

Pyrrolidinone derivatives

Since a compound represented by general formula (1), its pharmaceutically acceptable salt and a hydrate of the pharmaceutically acceptable salt have high antipsychotic activity, they may be used as an active ingredient for preparation of an antipsychotic. STR1 Also provided are an optical resolution method of the above compound and an intermediate for preparation of the compound.

Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives

As a part of our studies on the syntheses of benzoxazinorifamycin derivatives, 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives were synthesized, and tested for their antimicrobial activities. The antimicrobial activities of these compounds against gram-positive and gram-negative bacteria were almost identical to those of rifampicin (RFP) and rifabutain (RFB), however, antimicrobial activities against Mycobacterium tuberculosis were superior to RFP, while being similar to RFB. 3'-Hydroxy-5'-(4-alkyl-1-piperazinyl)benzoxazinorifamycin derivatives also had in vitro potent activities against Mycobacterium avium complex (MAC). Their minimal inhibitory concentration values against MAC were 2-256 times greater than RFP and RFB. Their in vivo efficacies against M. tuberculosis and MAC, after oral administration to mice, were superior to RFP and REB, except for RFB against M. tuberculosis activity in vivo. Although they were absorbed from the gastrointestinal tract, their plasma levels were lower than that of RFP. Among these 5'-(4-alkyl-1-piperazinyl) derivatives, 3'-hydroxy-5'-(4-isobutyl-1-piperazinyl)benzoxazinorifamycin, compound 19 (KRM-1648), was selected as the most promising and its preliminary pharmacokinetic characteristics in mice were investigated. Compound 19 was distributed much more in tissues, especially in spleen and lung, than in plasma and had a long elimination time from tissues.