627-42-9

Basic information

• Product Name: 2-Methoxyethyl chloride
• Synonyms: 1-chloro-2-methoxy-ethan;beta-chloroethylmethylether;Ethane, 1-chloro-2-methoxy-;ethane,1-chloro-2-methoxy;ether,2-chloroethylmethyl;2-CHLOROETHYL METHYL ETHER;2-METHOXYETHYL CHLORIDE;1-CHLORO-2-METHOXYETHANE
• CAS NO: 627-42-9
• Molecular Formula: C₃H₇ClO
• Molecular Weight: 94.54
• EINECS: 210-999-7
• Mol File: 627-42-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: -55 °C
• Boiling Point: 89-90 °C(lit.)
• Flash Point: 59 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.035 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.408(lit.)
• Storage Temp.: Flammables area
• Solubility: 80g/l
• Water Solubility: 60 g/L (20 C)
• BRN: 1731028
• CAS DataBase Reference: 2-Methoxyethyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxyethyl chloride(627-42-9)
• EPA Substance Registry System: 2-Methoxyethyl chloride(627-42-9)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-22
• Safety Statements: 36/37-23-16
• RIDADR: UN 3271 3/PG 2
• WGK Germany: 3
• F: 9
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 627-42-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 627-42-9 differently. You can refer to the following data:
1. 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.
2. 2-Chloroethyl methyl ether was used in the synthesis of acyclic nucleosides of thieno[2,3-d] pyrimidine derivatives.
3. 2-Chloroethyl methyl ether (2-Methoxyethyl chloride) was used in the synthesis of acyclic nucleosides of thieno[2,3-d]pyrimidine derivatives.

Chemical Properties

clear colorless to yellowish liquid

InChI:InChI=1/C3H7ClO/c1-5-3-2-4/h2-3H2,1H3

Upstream product

• 99418-55-0 2,2,2-trichloro-acetimidic acid-(2-methoxy-ethyl ester) 
• 110-71-4 1,2-dimethoxyethane 
• 1107601-58-0 NbCl₄(OCH₂CH₂OMe) 
• 107-30-2 chloromethyl methyl ether 
• 74-85-1 ethene 
• 67-56-1 methanol 
• 420-37-1 trimethoxonium tetrafluoroborate 
• 107-07-3 2-chloro-ethanol 
• 77-78-1 dimethyl sulfate 
• 109-86-4 2-methoxy-ethanol 
• 15454-33-8 chloromethanol 
• 473-29-0 N,N-Dichlorobenzenesulfonamide 
• 186581-53-3 diazomethane 

Downstream Products

• 832-41-7 N-(ethoxymethyl)-4-methylbenzenesulfonamide 
• 117341-26-1 2-<(2-Methoxyethyl)thio>chlorobenzene 
• 109417-60-9 1-bromo-2-(2-methoxyethoxy)benzene 
• 117341-27-2 2-<(2-Methoxyethyl)thio>bromobenzene 
• 133306-24-8 5-(2-Methoxy-ethyl)-1-methyl-1,5-dihydro-imidazo[4,5-c]quinolin-4-one 
• 108345-12-6 2,5-Bis-(2-methoxy-ethylsulfanyl)-[1,3,4]thiadiazole 
• 108366-86-5 15-Benzyloxymethyl-15-(2-methoxy-ethoxymethyl)-1,4,7,10,13-pentaoxa-cyclohexadecane 
• 22428-72-4 bis(2-methoxyethyl)sulfide 
• 77281-03-9 sodium 2-methoxyethanesulfonate 
• 80894-21-9 1-azido-2-methoxy-ethane 
• 36824-00-7 4-[2-(methoxy)ethoxy]-benzaldehyde 
• 118468-98-7 1-(2-methoxyethyl)-1H-benzo[d]imidazole 
• 354148-91-7 1-(2-methoxyethyl-5-methyl)benzimidazole 
• 114991-70-7 3-methoxy-4-(2-methoxyethoxy)benzaldehyde 

Relevant articles and documents

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Synthesis of novel poly(ethylene glycol)-containing imidazolium-functionalized phosphine ligands and their application in the hydrosilylation of olefins

A series of polyethylene glycol-containing imidazolium-functionalized phosphine ligands (mPEG-im-PPh2) were successfully synthesized and used in the rhodium-catalyzed hydrosilylation of olefins. The results indicate that the RhCl3/mPEG-im-PPh2 catalytic system exhibits both excellent activity and selectivity for the β-adduct. In addition, the catalytic system may be recycled at least six times.

Further insights into the chemistry of niobium and tantalum pentahalides with 1,2-dialkoxyalkanes: Synthesis of bromo- and iodoalkoxides, spectroscopic and computational studies

The room temperature reactions of a series of 1,2-dialkoxyalkanes ROCH 2CH(R′)OR′′ with MX5 (M = Nb, Ta; X = Br, I) in 1:1 ratio result in single C-O bond cleavage and high-yield formation of the halo-alkoxides MBr4[κ2-OCH 2CH(R′)OR′′] or [NbI4{κ 1-OCH2CH(R′)OR′′}]2, and equimolar amounts of the corresponding alkyl halides RX. The reaction of NbBr5 with 1,2-dimethoxyethane, dme, proceeds with preliminary formation of the ionic species [NbBr4(κ2-dme) (κ1-dme)][NbBr6], 3b, which has been identified by solution NMR at low temperature and conductivity analyses. The gas-phase structure of 3b has been optimized by DFT calculations, confirming that the dme ligands adopt bidentate and monodentate coordination, respectively. Although the formation of NbOBr3(dme), 4b, 1,4-dioxane and MeBr from NbBr 5/dme (ratio 1:2) is an exoergonic process (calculated ΔGr° = -115.96 kcal mol-1), it is inhibited at room temperature. High temperature conditions enhance the production of 1,4-dioxane at the expense of selectivity. The dinuclear species NbOBr3(dme)NbBr5 (Nb-O-Nb), 5b, (X-ray) has been isolated in modest yield as byproduct of the room temperature reaction of NbBr5 with dme. In general, the 1:2 molar reactions of NbX5 (X = Br, I) with ROCH2CH(R′) OR′′ occur with the exclusion of nearly one equivalent of organic reactant.