Synthesis of optically active N-aryl amino acid derivatives through the asymmetric petasis reaction catalyzed by a novel hydroxy-thiourea catalyst
Thiourea makes peptides: Asymmetric Petasis reactions with vinylboronates and α-iminoamides are effectively catalyzed by the novel hydroxy-thiourea catalyst 1 (up to 86% yield, 93% ee; see scheme). This reaction can be applied not only to the synthesis of