SYNTHESIS OF 5'-O-PHOSPHONOMETHYL-2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE BY USE OF P-METHOXYBENZYL AS A N3-PROTECTING GROUP.
Uridine derivatives are protected at N3-position with a p-methoxybenzyl group under Mitsunobu conditions.Selective removal is possible with ceric ammonium nitrate.The otherwise difficult to obtain 5'-O-phosphonomethyl d4U was prepared using thi