135154-88-0

Basic information

• Product Name: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL
• Synonyms: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL;S-TFBDOL;(3S)-4,4,4-Trifluorobutane-1,3-diol;S-TFBDOL, (2S)-2,4-Dihydroxy-1,1,1-trifluorobutane;1,3-Butanediol,4,4,4-trifluoro-, (S)- (9CI)
• CAS NO: 135154-88-0
• Molecular Formula: C₄H₇F₃O₂
• Molecular Weight: 144.09
• Mol File: 135154-88-0.mol

Chemical Properties

• Boiling Point: 188.1 °C at 760 mmHg
• Flash Point: 67.6 °C
• Appearance: /
• Density: 1.354 g/cm³
• Vapor Pressure: 0.168mmHg at 25°C
• Refractive Index: 1.37
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(135154-88-0)
• EPA Substance Registry System: (S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL(135154-88-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 135154-88-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL is utilized as a key building block in the synthesis of various pharmaceuticals and agrochemicals. Its distinctive structure contributes to the development of new and innovative products in these fields.
Used in Chemical Reactions and Processes:
(S)-4,4,4-TRIFLUOROBUTANE-1,3-DIOL is employed as a solvent in certain chemical reactions and processes. Its ability to dissolve a wide range of substances makes it a versatile and important chemical in the industry, facilitating the production of diverse organic compounds.

InChI:InChI=1/C4H7F3O2/c5-4(6,7)3(9)1-2-8/h3,8-9H,1-2H2/t3-/m0/s1

Upstream product

• 122818-66-0 (R)-6,6,6-Trifluoro-5-hydroxy-2-methyl-2-trimethylsilanyloxy-hexan-3-one 
• 85571-85-3 ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate 

Downstream Products

• 135859-37-9 4,4,4-trifluoro-3-hydroxybutyl 4-methylbenzenesulfonate 

Relevant articles and documents

STEREOCONTROLLED SYNTHESIS OF 4,4,4-TRIFLUOROTHREONINE

Stereoisomers of unnatural 4,4,4-trifluorothreonine are obtained through enzymatic resolution, and the absolute configuration of these materials is determined. 4,4,4-Trifluorothreonine thus prepared was evaluated for antifugal or antitumor activity.

Stereoselective Preparation of Ethyl 2,3-Dihydroxy-4,4,4-trifluorobutyrates via Enzymatic Optical Resolution

Ethyl 2,3-dihydroxy-4,4,4-trifluorobutyrate was prepared in a highly diastereo- as well as enantioselective manner via enzymatic optical resolution followed by chemical transformations with complete retention of their configurations.

The fluorine-containing α, β - production of unsaturated aldehydes

The purpose of the present invention is to provide a fluorine-containing alpha,beta-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing alpha,beta-unsaturated aldehyde, and a method for producing same. This method for producing a fluorine-containing alpha,beta-unsaturated aldehyde is a method for producing a fluorine-containing alpha,beta-unsaturated aldehyde represented by formula (1) and comprises: an oxidizing step of oxidizing an alcohol represented by formula (2) in a high-boiling-point solvent, which has a higher boiling point than the corresponding alpha,beta-unsaturated aldehyde, by using an oxidizing agent that is insoluble to the high-boiling-point solvent; and a purifying step of purifying the reaction solution obtained in the oxidizing step by distillation. In formulae (1) and (2), R1 and R2 each independently represent a hydrogen atom or a fluorine atom, and X is 2 or 3.

Practical synthesis of 4,4,4-trifluorocrotonaldehyde: A versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions

The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded t

Process for producing 4,4,4,- trifluoro-3-hydroxybutyric acid

A first process for producing an optically active perfluoroalkylcarbinol derivative includes (a) reacting an optically active imine with a compound that is a hemiacetal of a perfluoroalkylaldehyde or a hydrate of a perfluoroalkylaldehyde to obtain a conde