- Carbazole inhibitors of histamine receptors for the treatment of disease
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The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
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Page/Page column 47
(2012/01/04)
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- NMR study of C- and N-trimethylsilylazole derivatives
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C- and N-trimethylsilylazole derivatives were studied by 1H, 13C and 29Si NMR spectroscopy. Degenerated prototropic tautomerism of 4-trimethylsilylpyrazole in methanol and the silylotropy of 1-trimethylsilyl-4-methylpyrazole in a neat liquid were investigated for the first time. 3- and 5-tautomers of 3(5)-methylpyrazole in a ratio of 54:46 were found in methanol by use 13C NMR spectroscopy (Tc = 230 K, ΔGc ≠ = 10 kcal mol-1).
- Larina, Lyudmila I.,Sorokin, Mikhail S.,Albanov, Aleksandr I.,Elokhina, Valentina N.,Protsuk, Nadezhda I.,Lopyrev, Valentin A.
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p. 110 - 115
(2007/10/03)
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- Alkylation and acylation of the 1,2,3,triazole ring
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Trimethylsilylation of 1,2,3-triazole regioselectively proceeded to give 2-trimethylsilyl-2H-1,2,3-triazole, which was treated with primary alkyl halides in the presence of tetrabutylammonium fluoride to give 1-alkyl-1H- 1,2,3-triazoles as a Sole product 1-Methyl-5-substituted 1H-1,2,3-triazoles were prepared by alkylation of 5-lithio-1-methyl-1H-1,2,3-triazole, and 1- methyl-4-substituted 1H-1,2,3-triazoles were obtained by alkylation of 4- lithio-1-methyl-5-phenylthio-1H-1,2,3-triazole followed by reductive desulfurization.
- Ohta, Shunsaku,Kawasaki, Ikuo,Uemura, Takahiro,Yamashita, Masayuki,Yoshioka, Tomomichi,Yamaguchi, Satoshi
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p. 1140 - 1145
(2007/10/03)
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- Diheteroarylmethanes. 5. E-Z isomerism of carbanions substituted by 1,3-Azoles: 13C and 15N π-charge/shift relationships as source for mapping charge and ranking the electron-withdrawing power of heterocycles
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Previously proposed π-charge/shift relationships have been applied to 13C and 15N shifts of the carbanions of 2-benzylazoles (thiazole, oxazole, and imidazole), their corresponding benzo-fused analogs, and bis(2-azolyl)methanes (azol
- Abbotto, Alessandro,Bradamante, Silvia,Pagani, Giorgio A.
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p. 1761 - 1769
(2007/10/03)
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