13518-80-4

Usage

Uses

Used in Organic Synthesis:
2-Trimethylsilyl-1,2,3-triazole is used as a reagent in organic synthesis for its ability to participate in a wide range of reactions, contributing to the formation of complex organic molecules.
Used as a Protecting Group in Organic Chemistry:
In the synthesis of pharmaceuticals and agrochemicals, 2-Trimethylsilyl-1,2,3-triazole serves as a protecting group for alcohols and amines. Its stability and the ease of removal under mild conditions make it an ideal choice for protecting functional groups during chemical reactions.
Used in the Modification of Natural Products:
2-Trimethylsilyl-1,2,3-triazole is utilized in the modification of natural products to enhance their properties or introduce new functionalities. Its unique reactivity allows for selective modifications, which can be beneficial in the development of novel bioactive compounds.
Used in Pharmaceutical and Agrochemical Industries:
In the pharmaceutical and agrochemical industries, 2-Trimethylsilyl-1,2,3-triazole is employed in the synthesis of various compounds. Its versatility and reactivity contribute to the development of new drugs and agrochemicals with improved efficacy and selectivity.

InChI:InChI=1/C5H11N3Si/c1-9(2,3)8-6-4-5-7-8/h4-5H,1-3H3

Upstream product

• 288-36-8 1,2,3-triazole 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 75-77-4 chloro-trimethyl-silane 
• 288-36-8 1 ,2,3-Triazole 

Downstream Products

• 78910-06-2 1-ethyl-1H-1,2,3-triazole 
• 63778-00-7 2-phenethyl-2H-[1,2,3]triazole 
• 63777-90-2 2-phenylethyl-1H-1,2,3-triazole 
• 16681-65-5 1-methyl-1,2,3-triazole 
• 125888-76-8 (2S,3S,5R)-6,6-Dibromo-3-methyl-7-oxo-3-[1,2,3]triazol-1-ylmethyl-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 176961-50-5 2-(4-bromophenyl)oxazole 
• 68485-15-4 2-benzyl-oxazole 
• 62881-98-5 2-(2-chloro-phenyl)-oxazole 
• 4368-68-7 1-benzyl-1H-[1,2,3]triazole 

Relevant academic research and scientific papers

Carbazole inhibitors of histamine receptors for the treatment of disease

The present invention relates to carbazole compounds, pharmaceutical compositions comprising them, and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

NMR study of C- and N-trimethylsilylazole derivatives

C- and N-trimethylsilylazole derivatives were studied by 1H, 13C and 29Si NMR spectroscopy. Degenerated prototropic tautomerism of 4-trimethylsilylpyrazole in methanol and the silylotropy of 1-trimethylsilyl-4-methylpyrazole in a neat liquid were investigated for the first time. 3- and 5-tautomers of 3(5)-methylpyrazole in a ratio of 54:46 were found in methanol by use 13C NMR spectroscopy (Tc = 230 K, ΔGc ≠ = 10 kcal mol-1).

Alkylation and acylation of the 1,2,3,triazole ring

Trimethylsilylation of 1,2,3-triazole regioselectively proceeded to give 2-trimethylsilyl-2H-1,2,3-triazole, which was treated with primary alkyl halides in the presence of tetrabutylammonium fluoride to give 1-alkyl-1H- 1,2,3-triazoles as a Sole product 1-Methyl-5-substituted 1H-1,2,3-triazoles were prepared by alkylation of 5-lithio-1-methyl-1H-1,2,3-triazole, and 1- methyl-4-substituted 1H-1,2,3-triazoles were obtained by alkylation of 4- lithio-1-methyl-5-phenylthio-1H-1,2,3-triazole followed by reductive desulfurization.

Diheteroarylmethanes. 5. E-Z isomerism of carbanions substituted by 1,3-Azoles: 13C and 15N π-charge/shift relationships as source for mapping charge and ranking the electron-withdrawing power of heterocycles

Previously proposed π-charge/shift relationships have been applied to 13C and 15N shifts of the carbanions of 2-benzylazoles (thiazole, oxazole, and imidazole), their corresponding benzo-fused analogs, and bis(2-azolyl)methanes (azol