- Chiral proline-based P,O and P,N ligands for iridium-catalyzed asymmetric hydrogenation
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Two new classes of proline-based P,O and P,N ligands were prepared and applied in the iridium-catalyzed asymmetric hydrogenation of alkenes. Both types of ligands induced high enantioselectivities in the hydrogenation of trisubstituted C=C bonds. Iridium complexes derived from P,O ligands bearing sterically demanding amide or urea groups at the pyrrolidine N-atom proved to be especially efficient catalysts for the conjugate reduction of α,β-unsaturated esters and ketones, whereas analogous P,N ligands led to better results with dialkyl-phenyl-substituted alkenes and an allylic alcohol as substrates.
- Rageot, Denise,Pfaltz, Andreas
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p. 2176 - 2193
(2013/02/23)
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- Proline-based P,O ligand/iridium complexes as highly selective catalysts: Asymmetric hydrogenation of trisubstituted alkenes
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P,O joins the mix: P,O ligands (L1) form efficient iridium catalysts for the asymmetric hydrogenation of olefins. The proline-derived ligands lead to high enantioselectivities with several classes of alkenes, most notably with α,β-unsaturated carboxylic e
- Rageot, Denise,Woodmansee, David H.,Pugin, Benoet,Pfaltz, Andreas
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p. 9598 - 9601
(2011/12/05)
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