1352663-21-8Relevant articles and documents
Chiral proline-based P,O and P,N ligands for iridium-catalyzed asymmetric hydrogenation
Rageot, Denise,Pfaltz, Andreas
, p. 2176 - 2193 (2013/02/23)
Two new classes of proline-based P,O and P,N ligands were prepared and applied in the iridium-catalyzed asymmetric hydrogenation of alkenes. Both types of ligands induced high enantioselectivities in the hydrogenation of trisubstituted C=C bonds. Iridium complexes derived from P,O ligands bearing sterically demanding amide or urea groups at the pyrrolidine N-atom proved to be especially efficient catalysts for the conjugate reduction of α,β-unsaturated esters and ketones, whereas analogous P,N ligands led to better results with dialkyl-phenyl-substituted alkenes and an allylic alcohol as substrates.
