1353049-81-6Relevant articles and documents
Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases
Mizoi, Kenta,Takahashi, Masato,Haba, Masami,Hosokawa, Masakiyo
supporting information, p. 921 - 923 (2016/05/24)
We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results sugges
Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: An organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach
Chen, Xiaofei,Xiong, Fangjun,Chen, Wenxue,He, Qiuqin,Chen, Fener
, p. 2723 - 2728 (2014/04/17)
An efficient asymmetric synthesis of atorvastatin calcium has been achieved from commercially available diethyl 3-hydroxyglutarate through a novel approach that involves an organocatalytic enantioselective cyclic anhydride desymmetrization to establish C(
STATIN DERIVATIVES
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Page/Page column 27-28, (2012/01/13)
Dinitrate statins having improved pharmacological activity are described. They can be employed for treating and/or preventing several diseases, in particular acute coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.