- (2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake.
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(2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake.
- Kelley, James L.,Musso, David L.,Boswell, G. Evan,Soroko, Francis E.,Cooper, Barrett R.
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- N-(Substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof
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The invention relates to an N-(substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof, in particular to an N-(substituted sulfonyl)benzamide derivativeshown as general formula (I), preparation method thereof, medicinal salts of the derivative, and their application as therapeutics, especially as Nav1.7 inhibitors, wherein substituents in the general formula (I) shown in the description are defined the same as in the description.
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- ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.
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Paragraph 0272; 0273; 0274; 0819; 0820
(2017/06/12)
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- Heterocyclic pharmaceutical compounds and use
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Novel (2S, 3S, 5R) morpholinols of formula (I) STR1 together with the (+-)-(2R*,3R*,5S*) racemates thereof, and their salts, wherein X is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or a group --CH2 --X1 where X1 is cycloalkyl of 3 to 6 carbon atoms. The compounds have a variety of uses in human medicine, in particular in the treatment of mental disorders such as depression.
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