Copper-catalyzed highly regioselective 2-aryloxylation of 2,x-dihalopyridines
2,x-Dihalopyridines reacted with phenols catalyzed by CuI/TMEDA in the presence of Cs2CO3 in DMSO at 110 °C under nitrogen atmosphere for 24 h to afford 2-aryloxypyridines in good to high yields except p-nitrophenol. To expand this methodology, a vanilloid receptor ligand used in treatments was prepared in good yield. This method has potential utility in the synthesis of pharmaceuticals, agrochemicals and even natural products.
Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.
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Paragraph 0565; 0566; 0567; 0568; 0569; 0570
(2013/06/28)
NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
The invention relates to new piperidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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Page/Page column 48
(2012/06/30)
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