Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity.
A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.
Anti-arythmiques apparentes au procainamide II. Synthese et etude pharmacologique
Anti-arrhythmic agents related to procainamide II.Synthesis and pharmacological study.In view of their marked anti-arrhythmic activity, we continued our studies on the N--4-alkoxy-benzamidines described previously.We prepared p