The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus
C7-Substituted 2-hydroxyisoquinoline-1,3-diones inhibit the strand transfer of HIV integrase (IN) and the reverse-transcriptase-associated ribonuclease H (RNH). Hepatitis C virus (HCV) NS5B polymerase shares a similar active site fold to RNH and IN, sugge
Chen, Yue-Lei,Tang, Jing,Kesler, Matthew J.,Sham, Yuk Y.,Vince, Robert,Geraghty, Robert J.,Wang, Zhengqiang
p. 467 - 479
(2012/02/16)
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