cas 135484-74-1, 3-Bromo-2-formylaniline | Articles data ｜lookchem

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135484-74-1

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HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS
The present invention provides heterocyclic compounds of formula (I), which are therapeutically useful as CBP/EP300 inhibitors. These compounds are useful in the treatment and/or prevention of diseases or disorders mediated by CBP and/or EP300 in an individual. The present invention also provides preparation of the compounds and pharmaceutical compositions comprising at least one of the compounds of formula (I) or a pharmaceutically acceptable salt, or a stereoisomer or a tautomer, an N-oxide or an ester thereof.
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(2022/04/03)

Design of triple helix forming C-glycoside molecules
The modeling, synthesis, and characterization of oligomers containing 2-aminoquinazolin-5-yl 2′-deoxynucleotide residues are reported. The 2-aminoquinazoline residues sequence specifically bind via Hoogsteen base pairing as a third strand in the center of
Li, Jian-Sen,Fan, Yun-Hua,Zhang, Yi,Marky, Luis A.,Gold, Barry
p. 2084 - 2093
(2007/10/03)

Acid-catalysed Cyclisation of o-Sulphonamido Ketene Dithioacetal S-Oxides: A Novel Synthesis of the Indole Ring System
Treatment of o-sulphonamido aryl ketene dithioacetal S-oxides with hydrochloric acid in the presence of hydrogen sulphide gives 2-methylthioindoles.
Hewson, Alan T.,Hughes, Kevin,Richardson, Steward K.,Sharpe, David A.,Wadsworth, Alan H.
p. 1565 - 1569
(2007/10/02)

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1974296-18-8
5-bromoquinoline-3-carbonitrile

Chemical Properties

Boiling Point: 302.958 °C at 760 mmHg
Flash Point:137.024 °C
Density: 1.673 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index: 1.675
PKA: -0.72±0.10(Predicted)
PSA: 43.09000
LogP: 2.42500

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