Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2′-O-methyl oligoribonucleotides
Chimeric 2′-O-methyl oligoribonucleotides (2′-OMe ORNs) containing internucleotide linkages which were modified with phosphonoacetate (PACE) or thiophosphonoacetate (thioPACE) were prepared by solid-phase synthesis. The modified 2′-OMe ORNs contained a ce
Threlfall, Richard N.,Torres, Adrian G.,Krivenko, Angelika,Gait, Michael J.,Caruthers, Marvin H.
experimental part
p. 746 - 754
(2012/02/05)
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