- Novel enantioselective synthesis of penaresidin A and Allo-penaresidin A via the construction of a highly functionalized azetidine
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A new and highly enantioselective synthesis of penaresidin A has been achieved via the construction of a highly functionalized azetidine with the requisite stereogenic centers, which can also be regarded as an advanced intermediate for the synthesis of penaresidin B and penazetidine A.
- Liu, Ding-Guo,Lin, Guo-Qiang
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p. 337 - 340
(2007/10/03)
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- Synthesis of sphingosine relatives. Part 19. Synthesis of penaresidin A and B, azetidine alkaloids with actomyosin ATPase-activating properties
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Three stereoisomers of penaresidin A 1 and two stereoisomers of penaresidin B 2' (Scheme 5), azetidine alkaloids isolated from the Okinawan marine sponge Penares sp., have been synthesized.In the course of our synthetic study, the correct structure of penarisidin B has been shown to be not 2 but 2'.Natural penaresidin A is either (2S,3R,4S,15S,16S)- or (2S,3R,4S,15R,16R)-1 and natural penaresidin B is either (2S,3R,4S,15S)- or (2S,3R,4S,15R)-2'.
- Takikawa, Hirosato,Maeda, Takeshi,Seki, Masanori,Koshino, Hiroyuki,Mori, Kenji
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- Synthesis of penaresidin A, an azetidine alkaloid with actomyosin ATPase-activating property
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Three stereoisomers of pentaresidin A (1) an azetidine alkaloid isolated from the Okinawan marine sponge Penares sp., were synthesized. The natural penaresidin A must be either (2S,3R,4S,15S,16S)- or (2S,3R,4S,15R,16R)-1.
- Takikawa, Hirosato,Maeda, Takeshi,Mori, Kenji
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p. 7689 - 7692
(2007/10/02)
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