The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)-propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula I: and pharmaceutically acceptable salts thereof wherein the acyl group of the benzofuran derivative of the general formula II: where R represents C1-4 alkyl-, C1-4 alkoxy- or aryl group, is selectively cleaved and if desired, the resulting compound of formula I is transformed into its salt.
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(2013/06/04)
NOVEL PROCESS FOR THE PREPARATION OF DRONEDARONE
The subject of the invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-di-n-butylamino)- propoxy]benzoyl}benzofuran-5-yl]-methanesulfonamide of formula (I), and pharmaceutically acceptable salts thereof characterized in that, the acyl group of the benzofuran derivative of the general formula (II), where R represents C 1-4 alkyl-, C1-4 alkoxy- or aryl group - is selectively cleaved and if desired, the resulting compound of formula I is transformed into its salt.
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(2012/02/05)
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