437652-07-8

Basic information

• Product Name: 2-Butyl-5-[methanesulfonamido]benzofuran
• Synonyms: 2-Butyl-5-[methanesulfonamido]benzofuran;2-butyl-5-(methylsulphonamide)benzofuran;N-(2-Butyl-5-benzofuranyl)MethanesulfonaMide;2-Butyl-5-[methanesulfomido]benzofuran
• CAS NO: 437652-07-8
• Molecular Formula: C₁₃H₁₇NO₃S
• Molecular Weight: 267.34
• Product Categories: API;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Dronedarone intermeidate
• Mol File: 437652-07-8.mol

Chemical Properties

• Melting Point: 104-106?C
• Boiling Point: 399.861 °C at 760 mmHg
• Flash Point: 195.629 °C
• Appearance: /
• Density: 1.257
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 8.33±0.30(Predicted)
• CAS DataBase Reference: 2-Butyl-5-[methanesulfonamido]benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butyl-5-[methanesulfonamido]benzofuran(437652-07-8)
• EPA Substance Registry System: 2-Butyl-5-[methanesulfonamido]benzofuran(437652-07-8)

Safety Data

• Hazardous Substances Data: 437652-07-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Synthetic route

2-n-butyl-5-bromo-benzofuran (497225-66-8) + methanesulfonamide (3144-09-0) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
With bis(dibenzylideneacetone)-palladium(0); tert-butyl XPhos In 1,4-dioxane at 100℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere;	100%

5-amino 2-n-butyl benzofuran (141645-51-4) + methanesulfonyl chloride (124-63-0) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
With ammonia In tetrahydrofuran; tert-butyl methyl ether; water at 200℃;

2-(4-bromo-2-formylphenoxy)-hexanoic acid (497225-62-4) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C 2: tert-butyl XPhos; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere View Scheme

5-bromosalicyclaldehyde (1761-61-1) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 80 °C 2: sodium hydroxide; water / 20 - 40 °C 3: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C 4: tert-butyl XPhos; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere View Scheme

Ethyl 2-bromohexanoate (615-96-3) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 80 °C 2: sodium hydroxide; water / 20 - 40 °C 3: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C 4: tert-butyl XPhos; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere View Scheme

ethyl 2-(4-bromo-2-formylphenoxy)-hexanoate (1338547-28-6) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide; water / 20 - 40 °C 2: benzenesulfonyl chloride; triethylamine / toluene; water / 80 °C 3: tert-butyl XPhos; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 24 h / 100 °C / Inert atmosphere View Scheme

2-bromohexanoic acid (616-05-7) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 6 steps 1.1: thionyl chloride / 5 h / Reflux 2.1: aluminum (III) chloride / dichloromethane / Cooling with ice 2.2: 20 °C 3.1: sodium hydroxide / methanol / 4 h / 65 °C 4.1: sodium tetrahydroborate / 2 h 5.1: hydrogenchloride / water / 6 h / Reflux 6.1: tetrabutyl-ammonium chloride / tetrahydrofuran / 4 h / 60 °C / Reflux View Scheme

2-bromohexanoyl chloride (42768-46-7) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / dichloromethane / Cooling with ice 1.2: 20 °C 2.1: sodium hydroxide / methanol / 4 h / 65 °C 3.1: sodium tetrahydroborate / 2 h 4.1: hydrogenchloride / water / 6 h / Reflux 5.1: tetrabutyl-ammonium chloride / tetrahydrofuran / 4 h / 60 °C / Reflux View Scheme

4-methoxy-aniline (104-94-9) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 6 steps 1.1: chloroform / 2 h / Inert atmosphere 2.1: aluminum (III) chloride / dichloromethane / Cooling with ice 2.2: 20 °C 3.1: sodium hydroxide / methanol / 4 h / 65 °C 4.1: sodium tetrahydroborate / 2 h 5.1: hydrogenchloride / water / 6 h / Reflux 6.1: tetrabutyl-ammonium chloride / tetrahydrofuran / 4 h / 60 °C / Reflux View Scheme

4-methoxyacetanilide (51-66-1) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / dichloromethane / Cooling with ice 1.2: 20 °C 2.1: sodium hydroxide / methanol / 4 h / 65 °C 3.1: sodium tetrahydroborate / 2 h 4.1: hydrogenchloride / water / 6 h / Reflux 5.1: tetrabutyl-ammonium chloride / tetrahydrofuran / 4 h / 60 °C / Reflux View Scheme

3-(2-bromohexanoyl)-4-hydroxy acetylaniline → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium hydroxide / methanol / 4 h / 65 °C 2: sodium tetrahydroborate / 2 h 3: hydrogenchloride / water / 6 h / Reflux 4: tetrabutyl-ammonium chloride / tetrahydrofuran / 4 h / 60 °C / Reflux View Scheme

N-(2-butyl-3-oxo-5-benzofuranyl)acetamide → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / 2 h 2: hydrogenchloride / water / 6 h / Reflux 3: tetrabutyl-ammonium chloride / tetrahydrofuran / 4 h / 60 °C / Reflux View Scheme

2-n-butyl-5-aminobenzofuran hydrochloride (526196-90-7) + methanesulfonyl chloride (124-63-0) → N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8)

Conditions	Yield
With tetrabutyl-ammonium chloride In tetrahydrofuran at 60℃; for 4h; Reflux;

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + benzoyl chloride (98-88-4) → N-benzoyl-N'-(2-n-butyl-1-benzofuran-5-yl)-methanesulfonamide (1356536-12-3)

Conditions	Yield
With pyridine In dichloromethane at 10 - 20℃; for 6h;	100%
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide With pyridine In dichloromethane at 10℃; for 0.5h; Stage #2: benzoyl chloride In dichloromethane at 10℃; for 5.5h;

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → 2-butyl-5-methanesulfonamido-benzofuran sodium salt

Conditions	Yield
With sodium hydroxide In water at 5 - 70℃; Product distribution / selectivity;	95%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → 2-butyl-5-methanesulfonamido-benzofuran potassium salt

Conditions	Yield
With potassium hydroxide In water at 5 - 20℃; for 3h; Product distribution / selectivity;	94%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → 2-butyl-5-methanesulfonamido-benzofuran magnesium salt

Conditions	Yield
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide With potassium hydroxide In water for 0.5h; Stage #2: With magnesium chloride In water at 5 - 25℃; Product distribution / selectivity;	93.7%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → 2-butyl-5-methanesulfonamido-benzofuran calcium salt

Conditions	Yield
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide With potassium hydroxide In water for 0.5h; Stage #2: With calcium chloride In water at 5 - 25℃; Product distribution / selectivity;	92%

4-[3-(di-n-butylamino)-propoxy]-benzoic acid chloride hydrochloride + N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → dronedarone hydrochloride

Conditions	Yield
With iron(III) chloride In dichloromethane for 2h; Heating / reflux;	90%
aluminum (III) chloride In dichloromethane at 25℃; for 2h;	90%
Stage #1: 4-[3-(di-n-butylamino)-propoxy]-benzoic acid chloride hydrochloride; N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide With aluminum (III) chloride; tin(IV) chloride In dichloromethane at 20℃; for 3h; Stage #2: With hydrogenchloride

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + propionyl chloride (79-03-8) → N-ethoxycarbonyl-N'-(2-n-butyl-1-benzofuran-5-yl)-methanesulfonamide

Conditions	Yield
With pyridine In dichloromethane at 10 - 20℃; for 3.5h;	84%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-(2-butyl-3-chloro-1-benzofuran-5-yl)methanesulfonamide

Conditions	Yield
With N-chloro-succinimide In dichloromethane; acetonitrile at -8℃; for 2.33333h;	76%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → 2-butyl-5-methanesulfonamido-benzofuran lithium salt

Conditions	Yield
With lithium hydroxide In water at 0 - 20℃; for 9h;	74.5%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + 4-[(3-carbethoxyamino)-propoxy]benzoylchloride (1401355-78-9) → N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide (1401355-77-8)

Conditions	Yield
With iron(III) chloride In dichloromethane at 5 - 45℃;	72.1%
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide; 4-[(3-carbethoxyamino)-propoxy]benzoylchloride With iron(III) chloride In dichloromethane at 5 - 20℃; for 3.33333h; Stage #2: With water In dichloromethane at 40 - 45℃; for 0.833333h;
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide; 4-[(3-carbethoxyamino)-propoxy]benzoylchloride With iron(III) chloride In dichloromethane at 5 - 20℃; for 3.33333h; Stage #2: With water In dichloromethane at 40 - 45℃; for 0.833333h;
With iron(III) chloride In dichloromethane at 5 - 20℃; for 3.33333h;

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-(2-butyl-3-bromo-1-benzofuran-5-yl)methanesulfonamide

Conditions	Yield
With N-Bromosuccinimide In dichloromethane; acetonitrile at -8℃; for 3.5h;	71%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + 4-<3-(dibutylamino)propoxy>benzaldehyde (114980-27-7) → N-(2-butyl-3-((4-(3-(dibutylamino)propoxy)phenyl)(hydroxy)methyl)benzofuran-5-yl)methanesulfonamide (141644-94-2)

Conditions	Yield
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide With n-butyllithium In hexane at 20℃; for 2h; Stage #2: 4-<3-(dibutylamino)propoxy>benzaldehyde In tetrahydrofuran; hexane at 20℃; for 2h; Reagent/catalyst; Solvent; Temperature; Time; Concentration;	40%

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + 4-(3-chloropropoxy)benzoic acid chloride (65136-48-3) → N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide (1310430-05-7)

Conditions	Yield
Stage #1: N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide; 4-(3-chloropropoxy)benzoic acid chloride; iron(III) chloride In dichloromethane at 5 - 45℃; Stage #2: With water In dichloromethane at 40 - 45℃; for 1h; Product distribution / selectivity;

4-(3-bromopropoxy)benzoyl chloride (401840-61-7) + N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → C23H26BrNO5S (1310430-06-8)

Conditions	Yield
Stage #1: 4-(3-bromopropoxy)benzoyl chloride; N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide; iron(III) chloride In dichloromethane at 5 - 45℃; Stage #2: With water In dichloromethane at 40 - 45℃; for 1.16667h; Product distribution / selectivity;

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → dronedarone (141626-36-0)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iron(III) chloride / dichloromethane / 5 - 45 °C 1.2: 1 h / 40 - 45 °C 2.1: sodium iodide / butanone / 16 h View Scheme
Multi-step reaction with 2 steps 1.1: iron(III) chloride / dichloromethane / 5 - 45 °C 1.2: 1.17 h / 40 - 45 °C 2.1: sodium iodide / butanone / 16 h View Scheme
Multi-step reaction with 3 steps 1: pyridine / dichloromethane / 5.5 h / 10 - 20 °C 2: iron(III) chloride / dichloromethane / 5 - 40 °C 3: potassium methylate / methanol / 2 h / 60 °C View Scheme

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → dronedarone hydrochloride

Conditions	Yield
Multi-step reaction with 3 steps 1.1: iron(III) chloride / dichloromethane / 5 - 45 °C 1.2: 1 h / 40 - 45 °C 2.1: sodium iodide / butanone / 16 h 3.1: hydrogenchloride / isopropyl alcohol; water / 5 h / 0 °C View Scheme
Multi-step reaction with 3 steps 1.1: iron(III) chloride / dichloromethane / 5 - 45 °C 1.2: 1.17 h / 40 - 45 °C 2.1: sodium iodide / butanone / 16 h 3.1: hydrogenchloride / isopropyl alcohol; water / 5 h / 0 °C View Scheme

4-[3-(di-n-butylamino)-propoxy]-benzoic acid chloride hydrochloride + N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → dronedarone (141626-36-0)

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 0 - 10℃; for 20h;

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) + acetyl chloride (75-36-5) → N-acetyl-N'-(2-n-butyl-1-benzofuran-5-yl)-methanesulfonamide (1356536-10-1)

Conditions	Yield
With pyridine In dichloromethane at 10 - 20℃; for 5.5h;
With pyridine In dichloromethane at 10 - 20℃; for 5.5h;

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-[2-n-butyl-3-[4-[3-(di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-benzoyl-methanesulfonamide (1356536-09-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 6 h / 10 - 20 °C 2: aluminum (III) chloride / dichloromethane / 5 - 40 °C View Scheme

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-[2-n-butyl-3-[4-[3 (-di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-acetyl-methanesulfonamide (1356536-07-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 5.5 h / 10 - 20 °C 2: iron(III) chloride / dichloromethane / 5 - 40 °C View Scheme
Multi-step reaction with 2 steps 1.1: pyridine / dichloromethane / 5.5 h / 10 - 20 °C 2.1: dichloromethane / 0.25 h / 5 °C 2.2: 1 h / 20 °C View Scheme

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-[2-n-butyl-3-[4-[3-(di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-ethoxycarbonyl-methanesulfonamide

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / dichloromethane / 3.5 h / 10 - 20 °C 2: iron(III) chloride / dichloromethane / 5 - 40 °C View Scheme

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide (1026754-33-5)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iron(III) chloride / dichloromethane / 3.33 h / 5 - 20 °C 1.2: 0.83 h / 40 - 45 °C 2.1: sodium hydroxide / methanol / 3 h / Reflux 2.2: pH 6 View Scheme
Multi-step reaction with 2 steps 1.1: iron(III) chloride / dichloromethane / 3.33 h / 5 - 20 °C 1.2: 0.83 h / 40 - 45 °C 2.1: sodium hydroxide; water / methanol / 3 h / pH 6 / Reflux View Scheme
Multi-step reaction with 2 steps 1: iron(III) chloride / dichloromethane / 3.33 h / 5 - 20 °C 2: sodium hydroxide / methanol / 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: iron(III) chloride / dichloromethane / 5 - 45 °C 2: sodium hydroxide / methanol / 3 h / Reflux View Scheme

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-[2-n-butyl-3-[4-[3 (-di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-ethoxycarbonyl-methanesulfonamide (1356536-08-7)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: pyridine / dichloromethane / 3.5 h / 10 - 20 °C 2.1: dichloromethane / 0.25 h / 5 °C 2.2: 1 h / 20 °C View Scheme

N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide (437652-07-8) → N-[2-n-butyl-3-[4-[3(-di-n-butylamino)propoxyl]benzoyl]-1-benzofuran-5-yl]-N′-benzoyl-methanesulfonamide

Conditions	Yield
Multi-step reaction with 2 steps 1.1: pyridine / dichloromethane / 0.5 h / 10 °C 1.2: 5.5 h / 10 °C 2.1: dichloromethane / 0.25 h / 5 °C 2.2: 0.5 h / 35 - 40 °C View Scheme

Upstream product

• 141645-51-4 5-amino 2-n-butyl benzofuran 
• 124-63-0 methanesulfonyl chloride 
• 616-05-7 2-bromohexanoic acid 
• 42768-46-7 2-bromohexanoyl chloride 
• 104-94-9 4-methoxy-aniline 
• 51-66-1 4-methoxyacetanilide 
• 526196-90-7 2-n-butyl-5-aminobenzofuran hydrochloride 
• 1338547-28-6 ethyl 2-(4-bromo-2-formylphenoxy)-hexanoate 
• 615-96-3 Ethyl 2-bromohexanoate 
• 1761-61-1 5-bromosalicyclaldehyde 
• 497225-62-4 2-(4-bromo-2-formylphenoxy)-hexanoic acid 
• 497225-66-8 2-n-butyl-5-bromo-benzofuran 
• 3144-09-0 methanesulfonamide 

Downstream Products

• 141625-93-6 dronedarone hydrochloride 
• 141626-36-0 dronedarone 
• 1356536-09-8 N-[2-n-butyl-3-[4-[3-(di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-benzoyl-methanesulfonamide 
• 1356536-07-6 N-[2-n-butyl-3-[4-[3 (-di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-acetyl-methanesulfonamide 
• 1026754-33-5 N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide 
• 1401355-77-8 N-[2-butyl-3-{4-[(3-ethoxycarbonylamino)propoxy]benzoyl}-1-benzofuran-5-yl]-methanesulfonamide 
• 141644-94-2 N-(2-butyl-3-{[4-(3-dibutylaminopropoxy)-phenyl]-hydroxymethyl}-benzofuran-5-yl)-methanesulfonamide 
• 1448297-06-0 N-[2-butyl-3-(4-fluorobenzoyl)-1-benzofuran-5-yl]methanesulfonamide 
• 1356536-08-7 N-[2-n-butyl-3-[4-[3 (-di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-ethoxycarbonyl-methanesulfonamide 
• 1356536-12-3 N-benzoyl-N'-(2-n-butyl-1-benzofuran-5-yl)-methanesulfonamide 
• 1310430-06-8 C₂₃H₂₆BrNO₅S 
• 1310430-05-7 N-(2-butyl-3-(4-(3-chloropropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide 

Relevant articles and documents

Method for synthesizing [...] reach silom

The invention discloses a dronedarone synthesis method. According to the method, 4-[3-(dibutylamino)propoxy]methyl benzoate, 4-[3-(dibutylamino)propoxy]benzoic acid hydrochloride, 4-[3-(dibutylamino)propoxy]benzoyl chloride, 2-bromohexanoyl chloride, p-methoxyacetanilide, 3-(2-bromohexanoyl chloride)-4-hydroxyacetanilide, N-2-butyl-5-benzofuranamine hydrochloride, N-[(2-butyl-2,3-2H-5-benzofuran)methanesulfonamide], N-2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuran]-methanesulfonamide and dronedarone are obtained through step-reactions. The dronedarone synthesis method is simple in process, convenient to operate and high in rate of production.

PROCESS FOR PREPARING SULFONAMIDOBENZOFURAN DERIVATIVES

The invention relates to a process for preparing 5-sulfonamido-benzofuran derivatives of general formula: formula (I) in which R represents an alkyl or aryl group and R1 and R2 represent hydrogen or an alkyl or aryl group. According to the invention, the compounds of formula I are prepared by coupling a benzofuran derivative of general formula II, where X represents chlorine, bromine or iodine or a sulfonate group: formula (II) with a sulfonamide derivative of formula R—SO2—NH2, in the presence of a basic agent and of a catalyst system formed from a complex between a palladium compound and a ligand.

Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate

The invention relates to 2-butyl-5-(methanesulfonamido)benzofuran, its preparation and its use. This compound is a synthesis intermediate, in particular for the preparation of dronedarone.