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CAS

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1357171-62-0

ML-228, also known as N-([1,1''-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine, is a chemical compound that serves as an activator of the hypoxia-inducible factor (HIF) pathway. This pathway plays a crucial role in cellular responses to low oxygen levels, making ML-228 a potentially valuable compound in various applications.

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  • 1357171-62-0 Structure

  • Basic information

    1. Product Name: ML-228
    2. Synonyms: ML-228;N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
    3. CAS NO:1357171-62-0
    4. Molecular Formula: C27H21N5
    5. Molecular Weight: 415.48914
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1357171-62-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 686.0±65.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.228±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C, Inert atmosphere
    8. Solubility: DMSO (Slightly), Methanol (Slightly)
    9. PKA: 2.03±0.63(Predicted)
    10. CAS DataBase Reference: ML-228(CAS DataBase Reference)
    11. NIST Chemistry Reference: ML-228(1357171-62-0)
    12. EPA Substance Registry System: ML-228(1357171-62-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1357171-62-0(Hazardous Substances Data)

1357171-62-0 Usage

Uses

Used in Pharmaceutical Industry:
ML-228 is used as an activator for the hypoxia-inducible factor (HIF) pathway for its ability to modulate cellular responses to low oxygen levels. This makes it a promising candidate for the development of new therapeutic strategies targeting conditions related to hypoxia, such as certain types of cancer and other diseases where oxygen deprivation is a factor.
Used in Cancer Research:
In the field of cancer research, ML-228 is used as a tool to study the role of the HIF pathway in tumor growth and progression. By activating this pathway, researchers can gain insights into the mechanisms underlying cancer development and identify potential targets for therapeutic intervention.
Used in Drug Development:
ML-228 is also used in the development of new drugs targeting the HIF pathway. As an activator of this pathway, it can be utilized to design and synthesize novel compounds with improved pharmacological properties, potentially leading to more effective treatments for various diseases, including cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 1357171-62-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,1,7 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1357171-62:
(9*1)+(8*3)+(7*5)+(6*7)+(5*1)+(4*7)+(3*1)+(2*6)+(1*2)=160
160 % 10 = 0
So 1357171-62-0 is a valid CAS Registry Number.

1357171-62-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-([1,1'-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1357171-62-0 SDS

1357171-62-0Downstream Products

1357171-62-0Relevant articles and documents

Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway

Theriault, Jimmy R.,Felts, Andrew S.,Bates, Brittney S.,Perez, Jose R.,Palmer, Michelle,Gilbert, Shawn R.,Dawson, Eric S.,Engers, Julie L.,Lindsley, Craig W.,Emmitte, Kyle A.

, p. 76 - 81 (2012/02/16)

Hypoxia and ischemia are linked to several serious public health problems that affect most major organ systems. Specific examples include diseases of the cardiovascular, pulmonary, renal, neurologic, and musculoskeletal systems. The most significant pathw

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