135810-45-6

Basic information

• Product Name: 2-amino-7,10-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one
• CAS NO: 135810-45-6
• Molecular Formula: C₁₅H₁₄N₂O₂
• Molecular Weight: 254.2839
• Mol File: 135810-45-6.mol

Chemical Properties

• Boiling Point: 477.5°C at 760 mmHg
• Flash Point: 242.6°C
• Density: 1.265g/cm³
• Vapor Pressure: 2.79E-09mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 2-amino-7,10-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-7,10-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one(135810-45-6)
• EPA Substance Registry System: 2-amino-7,10-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one(135810-45-6)

Safety Data

• Hazardous Substances Data: 135810-45-6(Hazardous Substances Data)

Usage

Chemical compound

2-amino-7,10-dimethyldibenzo[b,f][1,4]oxazepin-11(10H)-one

Molecular structure

Complex

Derivative of

Dibenzo[b,f][1,4]oxazepine

Classification

Tricyclic heterocyclic compound

Medical use

Treatment of mental health disorders, including depression and bipolar disorder

Mechanism of action

Acts as a serotonin and norepinephrine reuptake inhibitor

Effect

Increases levels of neurotransmitters in the brain, helping to alleviate symptoms of depression and improve mood

Monitoring

Closely monitored due to potential for adverse side effects and interactions with other medications

Upstream product

• 135810-40-1 7,10-dimethyl-2-nitrodibenz<1,4>oxazepin-11(10H)-one 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 
• 135810-39-8 7-methyl-2-nitrodibenz<1,4>oxazepin-11(10H)-one 
• 140413-39-4 N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide 
• 865-33-8 potassium methanolate 

Downstream Products

• 140413-02-1 7,10-Dimethyl-11-oxo-10,11-dihydro-dibenzo[b,f][1,4]oxazepine-2-carbonitrile 
• 140412-88-0 7,10-Dimethyl-10H-dibenzo[b,f][1,4]oxazepin-11-one 

Relevant articles and documents

Dibenz[b,f][1,4]oxazepin(and thiazepin)-11(10H)-ones and-thiones and their use in the prevention or treatment of HIV infection

Disclosed is the use of dibenz[b,f][1,4]oxazepin (or thiazepin)-11(10H)-ones and -thiones in the prevention and treatment of AIDS, ARC and related disorders associated with HIV infection.

Novel Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2. Tricyclic Pyridobenzoxazepinones and Dibenzoxazepinones

Dibenzoxazepin-11(10H)-ones (III), pyridobenzoxazepin-6(5H)-ones (IV), and pyridobenzoxazepin-5(6H)-ones (V) were found to inhibit human immunodeficiency virus type 1 reverse transcriptase with IC50 values as 19 nM.A-ring substitution has a profound effect on activity, with appropriate substituents at the positions ortho and para to the lactam nitrogen providing dramatically enhanced potency.Substitution in the C-ring is generally neutral or detrimental to activity.Although a C-ring amino substituent at the position meta to the lactam carbonyl is generally beneficial to activity, it has essentially no effect when the A-ring is optimally substituted.Like the dipyridodiazepinone nevirapine, compounds III-V are specific for HIV-1 RT, exhibiting no inhibitory activity against HIV-2 RT or other virial reverse transcriptase enzymes.