25784-91-2

Basic information

• Product Name: 2-Chloro-5-nitrobenzoyl chloride
• Synonyms: 2-CHLORO-5-NITROBENZOYL CHLORIDE;2-chloro-5-nitro-benzoylchlorid;Benzoyl chloride, 2-chloro-5-nitro-;2-Chloro-5-Nitrobenzoyl;2-Chloro-5-nitrobenzoic acid chloride
• CAS NO: 25784-91-2
• Molecular Formula: C₇H₃Cl₂NO₃
• Molecular Weight: 220.01
• EINECS: 247-262-4
• Mol File: 25784-91-2.mol
• Article Data: 60

Chemical Properties

• Melting Point: 58-60°C
• Boiling Point: 157-158°C 11mm
• Flash Point: 157-158°C/11mm
• Appearance: /
• Density: 1.575g/cm³
• Vapor Pressure: 0.000705mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 2213721
• CAS DataBase Reference: 2-Chloro-5-nitrobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-nitrobenzoyl chloride(25784-91-2)
• EPA Substance Registry System: 2-Chloro-5-nitrobenzoyl chloride(25784-91-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-41
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• TSCA: T
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 25784-91-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-5-nitrobenzoyl chloride, also known as 5-Chloro-2-nitrobenzoyl chloride, is a chemical compound with the molecular formula C7H3ClNO3. It is a yellowish, crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Chloro-5-nitrobenzoyl chloride is highly reactive and is often used as a reagent in organic synthesis, particularly in the preparation of benzoyl chlorides and benzoyl isothiocyanates. It is also used in the manufacturing of dyes, pigments, and other fine chemicals. 2-Chloro-5-nitrobenzoyl chloride should be handled with care as it is corrosive and can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H3Cl2NO3/c8-6-2-1-4(10(12)13)3-5(6)7(9)11/h1-3H

Upstream product

• 95-51-2 o-chloroaniline 
• 16588-02-6 4-chloro-3-cyanonitrobenzene 
• 873-32-5 2-Chlorobenzonitrile 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 79-37-8 oxalyl dichloride 
• 16588-15-1 2-chloro-5-nitro-benzamide 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 85469-93-8 2-chloro-5-nitro-N-methylbenzamide 
• 70132-87-5 2-chloro-4'-methoxy-5-nitro-benzophenone 
• 70132-91-1 2-chloro-5-nitro-4'-chlorobenzophenone 
• 83909-69-7 N-benzyl-2-chloro-5-nitrobenzamide 
• 145747-97-3 (2-Chloro-5-nitro-phenyl)-(2,4-dimethoxy-phenyl)-methanone 
• 150929-63-8 2-chloro-N-<2-(1,2,3,4-tetrahydroisoquinolyl)>-5-nitrobenzamide 
• 150929-60-5 2-chloro-5-nitro-N-(1-pyrrolidinyl)benzamide 
• 1012342-14-1 2-chloro-5-nitro-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)-benzamide 
• 860564-22-3 2-mercapto-5-nitro-benzophenone 
• 148676-81-7 2-chloro-5-nitrobenzoyl isothiocyanate 
• 205309-72-4 2-chloro-N-cyanomethyl-N-methyl-5-nitrobenzamide 
• 197654-18-5 2-chloro-N-(4-fluorophenyl)-5-nitrobenzamide 
• 128566-14-3 (2-chloro-5-nitrophenyl)(3,4-dimethoxyphenyl)methanone 

Relevant articles and documents

Metal-Free Oxidative Condensation of Catechols, Aldehydes and NH4OAc towards Benzoxazoles

Benzoxazoles extensively exist in biologically active compounds, natural products, pharmaceuticals and functional materials. Thus, facile and green synthesis of such valuable compounds from easily available substrates will make a contribution to drug, material, and fine chemistry. A method for the synthesis of benzoxazoles from catechols, aldehydes and ammonium acetate is developed using NaIO4 as oxidant under metal- and additive-free conditions. A broad range of benzoxazoles including some fluorescent whitening agents, JTP-426467 and tafamidis analogues are synthesized in 56–95% yields with outstanding functional group tolerance. Mechanistic investigations suggest that an interesting o-iminocyclohexa-diene alcohol intermediate is involved in the reaction. These salient features of the protocol make it an alternative for the synthesis of benzoxazoles. (Figure presented.).

2-Aminopyrazine-functionalized MCM-41 nanoporous silica as a new efficient heterogeneous ligand for Cu-catalyzed allylic C–H bonds oxidation of olefins

In spite of the importance of the application of allylic C–H bond oxidation of olefins in organic synthesis and existence of the numerous reports, lots of limitations such as large excess of the olefin respect to the oxidant, low chemical yield, long time of reaction and a large amount of the catalyst were reminded. We introduced a novel catalytic system using functionalized MCM-41 as catalyst support to promote efficiency of this reaction. The heterogeneous ligand Pyr-MCM-41 was prepared by substituted 2-aminopyrazine ligand on functionalized MCM-41 with 3-chloropropyltrimthoxysilane and characterized by FT-IR, XRD, SEM, EDX, BET, TGA, CHN techniques. In situ immobilized Pyr-MCM-41 by copper (I) trifluoromethanesulfonate (CuOTf) was applied in direct catalytic esterification of inert C–H bonds in olefins using various peresters at room temperature.

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