- SYNTHESE DE LA TRIFLUOROMETHYL-VINYL-CETONE
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The synthesis of trifluoromethylvinylketone 6 is described.The metal hydride reduction of ethyl trifluoroacetoacetate 1 gives the glycol 2.Selective tosylation of 2 occurs on the primary hydroxyl group and leads to 3.Tosyl-chloride exchange produces the c
- Tordeux, M.,Wakselman, C.
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- The fluorine-containing α, β - production of unsaturated aldehydes
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The purpose of the present invention is to provide a fluorine-containing alpha,beta-unsaturated aldehyde, a method for producing same, an optically active fluorine-containing compound using the fluorine-containing alpha,beta-unsaturated aldehyde, and a method for producing same. This method for producing a fluorine-containing alpha,beta-unsaturated aldehyde is a method for producing a fluorine-containing alpha,beta-unsaturated aldehyde represented by formula (1) and comprises: an oxidizing step of oxidizing an alcohol represented by formula (2) in a high-boiling-point solvent, which has a higher boiling point than the corresponding alpha,beta-unsaturated aldehyde, by using an oxidizing agent that is insoluble to the high-boiling-point solvent; and a purifying step of purifying the reaction solution obtained in the oxidizing step by distillation. In formulae (1) and (2), R1 and R2 each independently represent a hydrogen atom or a fluorine atom, and X is 2 or 3.
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Paragraph 0091; 0095
(2017/09/26)
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- Nucleophilic trifluoromethylation of conjugate acceptors via phenyl trifluoromethyl sulfone
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A mild procedure for the conjugate addition of the trifluoromethyl anion to activated Michael acceptors such as arylidenemalononitriles (15 examples) and arylidene Meldrum's acids (9 examples) using phenyl trifluoromethyl sulfone through a reductive magnesium metal mediated procedure is described. The new methodology is used to prepare befloxatone, a reversible and selective monoamine oxidase A inhibitor.
- Sakavuyi, Kaumba,Petersen, Kimberly S.
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supporting information
p. 6129 - 6132
(2013/10/22)
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- Practical synthesis of 4,4,4-trifluorocrotonaldehyde: A versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions
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The practical synthesis of 4,4,4-trifluorocrotonaldehyde (1) and its application to enantioselective 1,4-additions are described. The organocatalytic 1,4-addition of 1 with several nucleophiles such as heteroaromatics, alkylthiols and aldoximes afforded t
- Shibatomi, Kazutaka,Narayama, Akira,Abe, Yoshiyuki,Iwasa, Seiji
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supporting information; experimental part
p. 7380 - 7382
(2012/10/08)
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- Synthesis and Spin-Trapping Chemistry of 5,5-Dimethyl-2-(trifluoromethyl)-1-pyrroline N-Oxide
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A new five-membered ring nitrone, 5,5-dimethyl-2-(trifluoromethyl)-1-pyrroline N-oxide (2-TFDMPO), is synthesized for the purpose of spin trapping in free radical biology.Most of the spin adducts of 2-TFDMPO are persistent, and EPR, ENDOR, and MS spectra can be obtained.A variety of radicals give characteristic spectral signatures, among which is a rare type of line width alternation pattern due to hindered rotation of the trifluoromethyl group.
- Janzen, Edward G.,Zhang, Young-Kang,Arimura, Masana
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p. 5434 - 5440
(2007/10/02)
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