135938-17-9

Basic information

• Product Name: 1-PIPERIDINYLETHYL-1H-INDOLE-3-CARBOXYLATE HYDROCHLORIDE
• Synonyms: 1-PIPERIDINYLETHYL-1H-INDOLE-3-CARBOXYLATE HCL H2O;SB 203186;SB 203186 HYDROCHLORIDE;SB203186HCl;1H-Indole-3-carboxylicacid,2-(1-piperidinyl)ethyl ester;2-(Piperidin-1-yl)ethyl 1H-indole-3-carboxylate hydrochloride;1H-Indole-3-carboxylic acid 2-piperidin-1-yl-ethyl ester
• CAS NO: 135938-17-9
• Molecular Formula: C16H21ClN2O2
• Molecular Weight: 308.8
• Mol File: 135938-17-9.mol

Chemical Properties

• Boiling Point: 457.8°Cat760mmHg
• Flash Point: 230.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.45E-08mmHg at 25°C
• Storage Temp.: Store at RT
• Solubility: H2O: 10 mg/mL
• PKA: 15.44±0.30(Predicted)
• CAS DataBase Reference: 1-PIPERIDINYLETHYL-1H-INDOLE-3-CARBOXYLATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PIPERIDINYLETHYL-1H-INDOLE-3-CARBOXYLATE HYDROCHLORIDE(135938-17-9)
• EPA Substance Registry System: 1-PIPERIDINYLETHYL-1H-INDOLE-3-CARBOXYLATE HYDROCHLORIDE(135938-17-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 135938-17-9(Hazardous Substances Data)

Usage

Uses

SB203186 is a potent 5HT4?serotonin receptor antagonist.

Biological Activity

Potent 5-HT 4 receptor antagonist with high affinity for human atrial 5-HT 4 receptors.

InChI:InChI=1/C16H20N2O2.ClH/c19-16(20-11-10-18-8-4-1-5-9-18)14-12-17-15-7-3-2-6-13(14)15;/h2-3,6-7,12,17H,1,4-5,8-11H2;1H

Upstream product

• 3040-44-6 1-piperidinoethanol 
• 59496-25-2 Indole-3-carbonyl chloride 

Relevant articles and documents

CONDENSED INDOLE DERIVATIVES AS 5HT4-RECEPTOR ANTAGONISTS

Compounds of formula (I) and pharmaceutically acceptable salts thereof: STR1 and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.

INDOLE DERIVATIVES

Disclosed are compounds of formula I STR1 wherein R 1 is a hydrogen atom, a C 1-C 6 alkyl group, benzyl or an indolyl carbonyl group, R 2 is a saturated or unsaturated 5-or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C 1-C 6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain--(CH 2) n--are optionally substituted by a C. sub.1-C 6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT 3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.