135969-88-9Relevant articles and documents
Synthesis of a series of highly substituted cyclohexanols via Michael addition in an aqueous medium
Lu, Guo-Ping,Cai, Chun
experimental part, p. 147 - 150 (2011/07/29)
The Michael addition of active methylene compounds or nitromethane to chalcones in an aqueous medium and catalysed by tetrabutyl ammonium hydroxide (TBAOH) to afford highly substituted cyclohexanols is described. The protocol provides an efficient route f
Tandem ring opening and oximation of ethyl 3-aroyl-1-cyano-4-hydroxy-2,4,6- triarylcyclohexanecarboxylate by hydroxylamine
Saravanan, Sivaperuman,Babu, Heeralal Vignesh,Muthusubramanian, Shanmugam
, p. 3635 - 3648 (2008/03/13)
The reaction of hydroxylamine hydrochloride with ethyl 3-aroyl-1-cyano-4- hydroxy-2,4,6-triarylcyclohexanecarboxylate has led to the formation of ethyl 2-[amino(hydroxyimino)methyl]-3-aryl-5-(hydroxyimino)-5-arylpentanoate via a tandem ring opening and ox
New aspects of Michael reaction: Reaction of 1,3-diarylpropenones with active cyano compounds
El-Sadany, S K,Sharaf, S M,Darwish, A I,Youssef, A A
, p. 567 - 573 (2007/10/02)
Ethyl 2-cyano-5-oxo-3,5-diarylpentanoates (7a-k) and 1,3,5-triaryl-2-aroyl-4-cyano-4-carboethoxycyclohexanols (6a-e,g,i,k) are obtained when the corresponding 1,3-diarylpropenones (1a-k) are reacted with ethyl cyanoacetate in the presence of different ratios of ethoxide ion.The cyclic products (6) are also obtained by treating the corresponding mono-condensation products (7) with sodium ethoxide.Furthermore, 3-aryl-4-benzoyl-2-phenylbutyronitriles (8) are obtained from the reaction of 1 with benzylcyanide in equimolar amounts in the presence of sodium ethoxide. 2-Benzoyl-4-cyano-1,3,4,5-tetraphenylcyclohexanol (9) is however, obtained when two moles of 1a are treated with one mole of benzylcyanide in the presence of ethoxide ion.The mono-condensation product 8 when treated with sodium ethoxide does not give 9.The cyclohexanol compound 11a is also obtained by the reaction of 1a with malononitrile.The structures of all the compounds have been established by elemental analysis and spectral data (IR, UV, 1H NMR and 13C NMR).
A UNIQUE TRIMOLECULAR MICHAEL REACTION AND CYCLIZATION
Al-Arab, Mohamed M.,Ghanem, Bader S.,Fitton, Alan O.
, p. 6545 - 6552 (2007/10/02)
1,3-Diaryl-2-propene-1-ones react with ethyl cyanoacetate in presence of sodium ethoxide at room temperature to give 2-aroyl-1,3,5-triaryl-4-carbethoxy-4-cyanocyclohexanols.The structure of the reaction products was established by infrared, H-1 and C-13 n
ON THE REACTION OF CHALCONE WITH ETHYL CYANOACETATE
Soto, J. L.,Seoane, C.,Mansilla, A. M.,Pardo, M. C.
, p. 4845 - 4848 (2007/10/02)
The recently reported condensation of chalcone with ethyl cyanoacetate is discussed and a cyclohexanol structure is proposed for the reaction product.