136-26-5

Basic information

• Product Name: N,N-bis(2-hydroxyethyl)decan-1-amide
• Synonyms: N,N-bis(2-hydroxyethyl)decan-1-amide;CAPRAMIDE DEA;Capric diethanolamide;Decanamide, N,N-bis(2-hydroxyethyl)-;N,N-Bis(2-hydroxyethyl)capric amide;N,N-Bis(2-hydroxyethyl)caprinamide
• CAS NO: 136-26-5
• Molecular Formula: C₁₄H₂₉NO₃
• Molecular Weight: 259.38496
• EINECS: 205-234-9
• Mol File: 136-26-5.mol

Chemical Properties

• Boiling Point: 417.9 °C at 760 mmHg
• Flash Point: 206.5 °C
• Appearance: /
• Density: 1.001 g/cm³
• Vapor Pressure: 9.88E-09mmHg at 25°C
• Refractive Index: 1.481
• PKA: 14.13±0.10(Predicted)
• CAS DataBase Reference: N,N-bis(2-hydroxyethyl)decan-1-amide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-hydroxyethyl)decan-1-amide(136-26-5)
• EPA Substance Registry System: N,N-bis(2-hydroxyethyl)decan-1-amide(136-26-5)

Safety Data

• Hazardous Substances Data: 136-26-5(Hazardous Substances Data)

Usage

Uses

Used in Detergent Industry:
N,N-bis(2-hydroxyethyl)decan-1-amide is used as a surfactant for its ability to reduce surface tension, which aids in the cleaning process and enhances the effectiveness of detergents.
Used in Emulsifier Industry:
N,N-bis(2-hydroxyethyl)decan-1-amide is used as an emulsifying agent to stabilize mixtures of oil and water, which is crucial in the formulation of various emulsion-based products.
Used in Personal Care Industry:
N,N-bis(2-hydroxyethyl)decan-1-amide is used as a component in personal care products to improve the texture and stability of formulations, as well as to provide a smooth application experience.
Used in Pharmaceutical Industry:
N,N-bis(2-hydroxyethyl)decan-1-amide is used as an excipient in the formulation of pharmaceuticals, where it can contribute to the solubility and stability of active ingredients.
Used in Food Industry:
N,N-bis(2-hydroxyethyl)decan-1-amide is used as a food additive to improve the texture and stability of food products, as well as to enhance the emulsification process in food manufacturing.

InChI:InChI=1/C14H29NO3/c1-2-3-4-5-6-7-8-9-14(18)15(10-12-16)11-13-17/h16-17H,2-13H2,1H3

Synthetic route

decanoic acid ethyl ester (110-38-3) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-decanamide (136-26-5)

Conditions	Yield
at 160℃;

1-decanoic acid (334-48-5) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-decanamide (136-26-5)

Conditions	Yield
Stage #1: 1-decanoic acid; 2,2'-iminobis[ethanol] With benzotriazol-1-ol; triethylamine In dichloromethane for 0.25h; Cooling with ice; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Cooling with ice;

N,N-bis-(2-hydroxy-ethyl)-decanamide (136-26-5) + epichlorohydrin (106-89-8) → C20H37NO5 (1421857-90-0)

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium hydroxide In water at 0 - 20℃; for 12.5h;

Upstream product

• 110-38-3 decanoic acid ethyl ester 
• 111-42-2 2,2'-iminobis[ethanol] 
• 334-48-5 1-decanoic acid 

Relevant articles and documents

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Non-viral gene vectors play an important role in the development of gene therapy. In this report, different hydrophobic chains were introduced into low molecular weight (LMW) PEI-based biodegradable oligomers to form a series of lipopolymers (LPs), and their structure-activity relationships were studied. Results revealed that the nine polymers can condense plasmid DNA well to form nanoparticles with appropriate sizes (120-250 nm) and positive zeta-potentials (+25-40 V). In vitro experiments were carried out and it was found that LP2 showed much higher transfection efficiency both in the presence and in the absence of serum under the polymer/DNA weight ratio of 0.8 in A549 cells.