136191-16-7

Basic information

• Product Name: 4-FLUORO-7-HYDROXY-1-INDANONE
• Synonyms: 4-FLUORO-7-HYDROXY-1-INDANONE;4-FLUORO-7-HYDROXYINDAN-1-ONE;4-fluoro-7-hydroxy-2,3-dihydro-1H-inden-1-one;4-Fluoro-2,3-dihydro-7-hydroxy-1H-inden-1-one;1H-Inden-1-one, 4-fluoro-2,3-dihydro-7-hydroxy-;4-FLUORO-7-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-ONE(WXC05104)
• CAS NO: 136191-16-7
• Molecular Formula: C₉H₇FO₂
• Molecular Weight: 166.15
• Mol File: 136191-16-7.mol

Chemical Properties

• Boiling Point: 335.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.412
• PKA: 10.30±0.20(Predicted)
• CAS DataBase Reference: 4-FLUORO-7-HYDROXY-1-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-7-HYDROXY-1-INDANONE(136191-16-7)
• EPA Substance Registry System: 4-FLUORO-7-HYDROXY-1-INDANONE(136191-16-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 136191-16-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-FLUORO-7-HYDROXY-1-INDANONE is used as a building block for the synthesis of biologically active molecules and drugs. Its unique chemical properties and structure contribute to the development of new compounds with improved properties, enhancing their therapeutic effects and safety profiles.
Used in Agrochemical Industry:
4-FLUORO-7-HYDROXY-1-INDANONE is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and properties can be utilized to design new compounds with enhanced efficacy and selectivity, improving crop protection and reducing environmental impact.
Used in Research and Development:
4-FLUORO-7-HYDROXY-1-INDANONE is used as a research tool for studying the structure-activity relationship of indanone derivatives. Its unique chemical properties and structure provide valuable insights into the design and optimization of new compounds with improved properties and biological activities.

Upstream product

• 127033-12-9 4-fluorophenyl 3-chloropropanoate 
• 371-41-5 4-Fluorophenol 

Downstream Products

• 127033-13-0 4-fluoro-7-methoxy-1-indanone 

Relevant articles and documents

6-OXO-1,6-DIHYDROPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF

A 6-oxo-1,6-dihydropyridazine derivative, a preparation method therefor and medical use thereof, in particular, a 6-oxo-1,6-dihydropyridazine derivative represented by general formula (I), a preparation method therefor, and a pharmaceutical composition containing the derivative, and use thereof as a NaV inhibitor and use thereof in the preparation of a drug for the treatment and/or prevention of pain and pain-related diseases. Each substituent in general formula (I) is the same as defined in the description.

Compound and application of compound in preparation of medicines

The invention discloses a compound and its application in a medicine. the invention specifically provides a compound as shown in the formula (I) or a stereisomer, a geometrical isomer, a tautomer, a racemate, nitric oxide, hydrate, a solvate, a metabolite, pharmaceutically acceptable salts or a prodrug of the compound as shown in the formula (I). The invention also discloses an application of the compound in preparation of a medicine. The medicine is used in treating cancers.

Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors

With the goal of improving metabolic stability and further enhancing FBPase inhibitory activity, a series of tricyclic 8H-indeno[1,2-d][1,3]thiazoles was designed and synthesized with the aid of structure-based drug design. Extensive SAR studies led to th

Bicyclic amino-substituted compounds

A compound of formula (I), wherein X is O, CH 2, S, SO or SO 2 ; R is F or Cl; R 1 is H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 2 is H, C 1 -C 6 alkyl or C 2 -C 6 alkenyl; R 3 is H, C 1 -C 6, alkyl, a pharmaceutically acceptable salt thereof, an enantiomer thereof, and a pharmaceutically acceptable salt of said enantiomer for use in therapy. A pharmaceutical preparation containing as active ingredient any one of said compounds. A process for the preparation of a compound of formula (I).