127033-13-0

Basic information

• Product Name: 4-Fluoro-7-Methoxy-1-indanone
• Synonyms: 4-Fluoro-7-Methoxy-1-indanone;4-Fluoro-7-methoxy-2,3-dihydro-1H-inden-1-one;4-Fluoro-7-methoxy-indan-1-one;4-fluoro-7-methoxy-2,3-dihydro-1H-inden-1-one(WXC07157)
• CAS NO: 127033-13-0
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.1756632
• Mol File: 127033-13-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 316.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-Fluoro-7-Methoxy-1-indanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-7-Methoxy-1-indanone(127033-13-0)
• EPA Substance Registry System: 4-Fluoro-7-Methoxy-1-indanone(127033-13-0)

Safety Data

• Hazardous Substances Data: 127033-13-0(Hazardous Substances Data)

Usage

General Description

4-Fluoro-7-Methoxy-1-indanone is a chemical compound with the molecular formula C10H9FO2. It is a white to off-white crystalline powder with a molecular weight of 182.17 g/mol. 4-Fluoro-7-Methoxy-1-indanone is used as a reagent in the synthesis of various pharmaceutical and agrochemical products. It may also be used as a precursor in the production of other organic compounds. Additionally, 4-Fluoro-7-Methoxy-1-indanone has potential applications in research and development, particularly in the fields of medicinal chemistry and drug discovery. However, it is important to handle and use this chemical with care, following all necessary safety precautions and regulations.

Upstream product

• 136191-16-7 4-Fluoro-7-hydroxy-indan-1-one 
• 77-78-1 dimethyl sulfate 
• 91319-46-9 3-(2-fluoro-5-methoxyphenyl)propanoic acid 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 371-41-5 4-Fluorophenol 
• 127033-12-9 4-fluorophenyl 3-chloropropanoate 
• 74-88-4 methyl iodide 

Downstream Products

• 127126-25-4 Benzyl-((S)-5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 127126-23-2 Benzyl-((R)-5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 127033-15-2 Benzyl-(5-fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-amine 
• 127126-21-0 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin 
• 127126-18-5 (R)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin 
• 764616-76-4 (S)-5-Fluoro-8-methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine 

Relevant articles and documents

Design, synthesis, and characterization of oxadiazolopyrazine analogs with application as anticancer agents

Here, we describe the synthesis and evaluation of a class of cell-permeable indeno-oxadiazolopyrazine analogs as the anticancer agents. A new and facile approach to the synthesis of substituted analogs of indeno-oxadiazolopyrazine is illustrated. We find that the designed indeno-oxadiazolopyrazines, 3, 4, 10, 11, 15, and 16, act as potent anticancer agents compared to camptothecin, topoisomerase I inhibitor. These observations suggest that the electron-donating group (methoxy) at the C-5, C-6, and C-8 positions or electron-withdrawing group (fluoro) at the C-6 and C-7 positions on the A ring of indeno-oxadiazolopyrazines is required for antiproliferative activities against MDA-MB-231, BT549, and MCF7 cell lines.

(S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: A Putative 5-HT1A-Receptor Antagonist

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