136411-21-7

Basic information

• Product Name: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine
• Synonyms: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine;5-bromo-4-(trifluoromethyl)thiazol-2-amine;5-broMo-4-(trifluoroMethyl)-1,3-thiazol-2-aMine;2-ThiazolaMine,5-broMo-4-(trifluoroMethyl)-;5-Bromo-4-trifluoromethyl-thiazol-2-ylamine;5-Bromo-4-(trifluoromethyl)
• CAS NO: 136411-21-7
• Molecular Formula: C₄H₂BrF₃N₂S
• Molecular Weight: 247.0362896
• Mol File: 136411-21-7.mol

Chemical Properties

• Boiling Point: 272.951 °C at 760 mmHg
• Flash Point: 118.877 °C
• Appearance: /
• Density: 1.99 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.18±0.10(Predicted)
• CAS DataBase Reference: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine(136411-21-7)
• EPA Substance Registry System: 5-bromo-4-trifluoromethyl-thiazole-2-ylamine(136411-21-7)

Safety Data

• Hazardous Substances Data: 136411-21-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-bromo-4-trifluoromethyl-thiazole-2-ylamine is used as a building block for the synthesis of various pharmaceutical drugs. Its unique structure and properties make it a valuable molecule for the development of new treatments for various diseases.
Used in Agrochemical Industry:
5-bromo-4-trifluoromethyl-thiazole-2-ylamine is used as a building block for the synthesis of agrochemical compounds. Its potential applications in this industry can contribute to the development of new and effective agrochemical products.
Used in Medicinal Chemistry Research:
5-bromo-4-trifluoromethyl-thiazole-2-ylamine is used as a research molecule in medicinal chemistry. Its diverse biological activities and unique structure make it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C4H2BrF3N2S/c5-2-1(4(6,7)8)10-3(9)11-2/h(H2,9,10)

Upstream product

• 349-49-5 4-(trifluoromethyl)-1,3-thiazol-2-amine 

Downstream Products

• 1211525-16-4 5-bromo-4-(trifluoromethyl)thiazole 
• 869854-05-7 2-{4-[2-amino-4-(trifluoromethyl)thiazol-5-ylthio]phenyl}-1,1,1-trifluoropropan-2-ol 
• 682342-69-4 N-(5-bromo-4-trifluoromethylthiazol-2-yl)-3,4-dicloro-benzamide 

Relevant articles and documents

2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

2-(1H-lndole-3-carbonyl)-thiazole-4-carboxamide derivatives and the corresponding imidazole, oxazole and thiophene derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 27 to 32 and 59 to 219; examples 1 to 8; compounds 1-1 to 1-97; tables 1-a, 2 and 3).

HETEROCYCLIC SULFONE MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric

ARYL SULFONES AND USES RELATED THERETO

Aryl sulfone compounds of formula (I) and (II) are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders.

Reactions of a 4-(Trifluoromethyl)thiazole Dianion

Treatment of 2-trifluoroacetamido-4-(trifluoromethyl)thiazole with two equivalents of n-butyllithium at -78 deg C produced the thiazole dianion 5 in situ, which reacted preferentially at the 5-position with a variety of electrophiles.These electrophiles include: an aldehyde, ketone, chloroformate, acid chloride, phosphorus oxychloride, silicon chloride, and disulfide.Dianion 5 also combined with dibromodifluoromethane at -98 deg C to give the corresponding 5-(bromodifluoromethyl)thiazole 7, which is an unusual reaction for an aromatic or heteroaromatic system.Compound 7 was converted to a 4,5-bis-(trifluoromethyl)thiazole 8 using tetrabutylammonium fluoride.