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349-49-5

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349-49-5 Usage

Uses

4-(Trifluoromethyl)-2-thiazolamine can be used to prepare phenethylthiazolylthiourea analogs as HIV-1 reverse transcriptase inhibitors. 4-(Trifluoromethyl)-2-thiazolamine can also be used to synthesize 2-amino benzamide derivatives as allosteric glucokinase activators.

Check Digit Verification of cas no

The CAS Registry Mumber 349-49-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 349-49:
(5*3)+(4*4)+(3*9)+(2*4)+(1*9)=75
75 % 10 = 5
So 349-49-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H3F3N2S/c5-4(6,7)2-1-10-3(8)9-2/h1H,(H2,8,9)

349-49-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(trifluoromethyl)-1,3-thiazol-2-amine

1.2 Other means of identification

Product number -
Other names 4-trifluoromethyl-thiazol-2-ylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:349-49-5 SDS

349-49-5Relevant articles and documents

A novel access to 4-trifluoromethyl-1,3-thiazole derivatives via an intermediate thiocarbonyl ylide

Obijalska, Emilia,B?aszczyk, Magdalena,Kowalski, Marcin K.,Mlostoń, Grzegorz,Heimgartner, Heinz

, p. 35 - 40 (2019/02/25)

A Lewis acid catalyzed reaction of trifluoroacetyldiazomethane (CF3COCHN2) with thiourea occurs in boiling THF solution in the presence of BF3·OEt2 yielding 2-amino-4-trifluoromethyl-1,3-thiazole in a fair yield

Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis c virus replication

Stachulski, Andrew V.,Pidathala, Chandrakala,Row, Eleanor C.,Sharma, Raman,Berry, Neil G.,Lawrenson, Alexandre S.,Moores, Shelley L.,Iqbal, Mazhar,Bentley, Joanne,Allman, Sarah A.,Edwards, Geoffrey,Helm, Alison,Hellier, Jennifer,Korba, Brent E.,Semple, J. Edward,Rossignol, Jean-Francois

supporting information; experimental part, p. 8670 - 8680 (2012/02/16)

We report the activities of a number of thiazolides [2-hydroxyaroyl-N- (thiazol-2-yl)amides] against hepatitis C virus (HCV) genotypes IA and IB, using replicon assays. The structure-activity relationships (SARs) of thiazolides against HCV are less predic

CARBACEPHEM β-LACTAM ANTIBIOTICS

-

Page/Page column 92, (2010/04/06)

Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

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