136463-67-7

Basic information

• Product Name: 1H-1-Benzazepine-3-carboxamide, 2,3,4,5-tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-, (2R,3R,5R)-rel-
• Synonyms: 1H-1-Benzazepine-3-carboxamide, 2,3,4,5-tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-, (2R,3R,5R)-rel-
• CAS NO: 136463-67-7
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.44
• Mol File: 136463-67-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-1-Benzazepine-3-carboxamide, 2,3,4,5-tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-, (2R,3R,5R)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1-Benzazepine-3-carboxamide, 2,3,4,5-tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-, (2R,3R,5R)-rel-(136463-67-7)
• EPA Substance Registry System: 1H-1-Benzazepine-3-carboxamide, 2,3,4,5-tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-, (2R,3R,5R)-rel-(136463-67-7)

Safety Data

• Hazardous Substances Data: 136463-67-7(Hazardous Substances Data)

Usage

Molecular structure

The molecule has a benzazepine core structure with a phenyl substitution, indicating a complex structure.

Chiral compound

The compound has (2R,3R,5R) stereochemistry, indicating a specific spatial orientation of the substituent groups.

Biological activity

The unique structure, stereochemistry, and substituent groups of the compound may result in various biological activities or pharmaceutical applications.

Upstream product

• 67-56-1 methanol 
• 136463-56-4 (2aR^*4RS^*9aR^*) 1-phenyl-2a,4,9-trmethyl-1,2a,3,4,9,9a-hexahydro-2H-azeto <2,3-b> <1> benzoazepin-2-one 

Relevant articles and documents

Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines

Five sets of heterocyclic derivatives of various sizes and complexities coupled by an amidine function to putrescine, spermidine, or spermine were prepared. They were essentially tested to determine the influence of the polyamine chain on their cellular t

Depletion of polyamines potentiates the antitumour effect of tetracyclic amidines bearing a putrescine moiety

D,L-2-(Difluoromethyl) ornithine (DFMO), a potent inactivator of putrescine biosynthesis that depletes spermidine levels in cells, is known to enhance cytotoxicity of DNA-binding drugs. A significant in-vitro cytotoxicity and DNA-binding affinity found fo