- Enantiomerically pure tetrahydroisoquinolines by enzyme catalysis and gold-catalyzed phenol synthesis
-
Five different furfural derivatives were converted to chiral cyanohydrins by enzyme catalysis in good enantiomeric excess. After a sequence of silyl protection, nitrile reduction, tosylation and propargylation, substrates for the gold(I) catalyzed cyclois
- Hashmi, A. Stephen K.,Ata, Filiz,Haufe, Patrick,Rominger, Frank
-
experimental part
p. 1919 - 1927
(2009/06/20)
-
- A practical high through-put continuous process for the synthesis of chiral cyanohydrins
-
A practical high through-put continuous process for the synthesis of chiral cyanohydrins is reported. Pretreated almond meal (or other solid raw enzyme sources) was loaded in a column to form a reactor, to which were attached a supplying system to deliver
- Chen, Peiran,Han, Shiqing,Lin, Guoqiang,Li, Zuyi
-
p. 8251 - 8253
(2007/10/03)
-
- A study of asymmetric hydrocyanation of heteroaryl carboxaldehydes catalyzed by (R)-oxynitrilase under micro-aqueous conditions
-
A number of new optically active heteroaryl cyanohydrins have been prepared by hydrocyanation under micro-aqueous conditions catalyzed by almond meal (containing (R)-oxynitrilase). Substituent effects on the reaction are discussed. This micro-aqueous meth
- Chen, Peiran,Han, Shiqing,Lin, Guoqiang,Huang, Hao,Li, Zuyi
-
p. 3273 - 3279
(2007/10/03)
-
- Synthesis of optically active cyanohydrins using almond meal
-
Asymmetric hydrocyanation of aldehydes was accomplished using almond meal, containing the enzyme oxynitrilase. Optically active cyanohydrins with high levels of enantiomeric purity were obtained following a simple procedure.
- Zandbergen,Van der Linden,Brussee,Van der Gen
-
p. 1387 - 1391
(2007/10/02)
-
- Asymmetric Hydrocyanation of a Range of Aromatic and Aliphatic Aldehydes
-
A range of aryl, alkyl and heterocyclic aldehydes have been treated with hydrogen cyanide in the presence of the 'Inoue' catalyst, (R,R)- or (S,S)-cyclo.Most aryl aldehydes with electron-donating substituents in the m-or p-positions give high enantiomeric excess (e.e) values (>=80percent) but aryl aldehydes with strong electron-withdrawing substituents gave moderate e.e. values (=50percent).These moderate values are believed to be due to partial racemization of the product cyanohydrins in the presence of the mildly basic catalyst.In contrast to the reactions of aryl aldehydes, reactions of alkyl aldehydes and of ketones gave low e.e. values (=30percent) and an explanation is proposed.
- Matthews, Barry R.,Jackson, W. Roy,Jayatilake, Gamini S.,Wilshire, Colin,Jacobs, Howard A.
-
p. 1697 - 1710
(2007/10/02)
-