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1-{4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl}-1H-indole-2,3-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 136611-38-6 Structure
  • Basic information

    1. Product Name: 1-{4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl}-1H-indole-2,3-dione
    2. Synonyms: 1-{4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl}-1H-indole-2,3-dione
    3. CAS NO:136611-38-6
    4. Molecular Formula: C24H16N2O4
    5. Molecular Weight: 396.39484
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 136611-38-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-{4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl}-1H-indole-2,3-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-{4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl}-1H-indole-2,3-dione(136611-38-6)
    11. EPA Substance Registry System: 1-{4-[(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)methyl]benzyl}-1H-indole-2,3-dione(136611-38-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 136611-38-6(Hazardous Substances Data)

136611-38-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 136611-38-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,6,1 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 136611-38:
(8*1)+(7*3)+(6*6)+(5*6)+(4*1)+(3*1)+(2*3)+(1*8)=116
116 % 10 = 6
So 136611-38-6 is a valid CAS Registry Number.

136611-38-6Downstream Products

136611-38-6Relevant articles and documents

Microwave-Assisted Catalyst Free Three Component Synthesis of Mono and Bis Spiro Pyrazolopyridines in Solvent Free Reaction

Nikpassand, Mohammad,Zare Fekri, Leila,Jamshidi, Neda

, p. 1580 - 1583 (2015)

Multicomponent synthesis of mono and bis-spiro pyrazolopyridines from isatin derivatives, indanedione, and 3-methyl-5-aminopyrazole under microwave irradiation in the absence of any catalyst or solvent with high yield and short reaction time is reported.

Bis(indoline-2,3-diones): Versatile precursors for novel bis(spirooxindoles) incorporating 4H-chromene-3-carbonitrile and pyrano[2,3-d]pyrimidine-6-carbonitrile derivatives

Ghozlan, Said Ahmed Soliman,Ramadan, Muhammed Aly,Abdelmoniem, Amr Mohamed,Elwahy, Ahmed H. M.,Abdelhamid, Ismail Abdelshafy

, p. 410 - 419 (2017)

Multicomponent reaction of dimedone or 1,3-dimethylbarbituric acid and malononitrile with a series of bis(indoline-2,3-diones) afforded the corresponding bis(2-amino-7,7-dimethyl-2’,5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3’-indoline]-3-carbonitrile) and bis(7’-amino-1’,3’-dimethyl-2,2’,4’-trioxo-1’,2’,3’,4’-tetrahydrospiro[indoline-3,5’-pyrano [2,3-d]pyrimidine]-6’-carbonitrile) derivatives in good to excellent yield.

Hantzsch reaction with bis-indole-2,3-diones: Synthesis of novel bis-spirocyclic oxindole incorporating acridine, dipyrazolo[3,4-b:4',3'-e]pyridine and pyrido[2,3-d:6,5-d']dipyrimidine

Abdelmoniem, Amr M.,Abdelrahman, Mohamed G. M.,Ghozlan, Said A. S.,Elwahy, Ahmed H. M.,Abdelhamid, Ismail A.

, p. 1814 - 1824 (2021)

One-pot three-component cyclo-condensation reaction of bis(indole-2,3-diones) with dimedone, 3-methyl-1H-pyrazol-5(4H)-one, or 6-aminouracil in boiling acetic acid afforded bis-spirocyclic oxindoles linked to acridine, dipyrazolo[3,4-b:4',3'-e]pyridine, a

Synthesis of isatin and 5-bromoisatin derivatives

Mesropyan,Ambartsumyan,Avetisyan,Sarkisyan,Amazaspyan

, p. 1476 - 1477 (2001)

New N-derivatives of isatin were synthesized by treating ethyl chloroacetate, N-(2-chloroethyl)-morpholine, and 1,4-di(chloromethyl)benzene with isatin sodium salt. N-Derivatives of isatin and 5-bromoisatin were also prepared by Mannich reaction.

DIMERS OF COVALENT NFKB INHIBITORS

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Paragraph 00107; 00108, (2018/07/29)

Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.

Eco-friendly multi-component synthesis of γ-spiroiminolactones in water

Safaei, Hamid Reza,Shekouhy, Mohsen

, p. 1020 - 1029 (2018/01/17)

γ-Spiroiminolactone derivatives can be synthesized through an one-pot three-component reaction of cyclic carbonyl compounds (isatin, acenaphthoquinone, ninhydrin), activated a-methylene carbonyl groups and isocyanides in water using sodium dodecyl sulfate (SDS) as a commercially available and cheap surfactant compound. All products were obtained in good to excellent yields without formation of any by-products in water as a green and benign reaction medium. Moreover, presented method was successfully applied for the synthesis of some novel bis(spiroiminolactone) derivatives.

Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity: Via sequential multi-component reaction in PEG-400 as a biodegradable solvent

Safari, Ensieh,Maryamabadi, Ammar,Hasaninejad, Alireza

, p. 39502 - 39511 (2017/08/26)

A green and efficient one-pot, sequential, multi-component protocol has been developed for the synthesis of some novel symmetrical bis-spirooxindole derivatives from the reaction of isatins, dihalides, malono derivatives and C-H activated carbonyl compoun

Novel mono- and bis(spiro-2-amino-4 H -pyrans): Alum-catalyzed reaction of 4-hydroxycoumarin and malononitrile with isatins, quinones, or ninhydrin

Karimi, Ali Reza,Sedaghatpour, Fahime

experimental part, p. 1731 - 1735 (2010/07/03)

Some new mono- and bis(spiro-2-amino-4H-pyrans) are synthesized by the multicomponent condensation reaction of 4-hydroxycoumarin and malononitrile with isatins, ninhydrin, 9,10-phenanthrenequinone, or acenaphthenequinone. Alum was found to be a suitable and efficient catalyst for this condensation. Georg Thieme Verlag Stuttgart - New York.

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