623-25-6

Basic information

• Product Name: alpha,alpha'-Dichloro-p-xylene
• Synonyms: P-XYLYLENE CHLORIDE;P-XYLENE DICHLORIDE;α,αˊ-Dichloro-1,4-xylene;a-a'Dichloro-P-Xylene(1:4BisChloroMethylP-Xylene);Alpha,Alpha'-Dichloro-P-Xylene,~95%;p-Xylylenedichloride,98%;a,a-Dichloroxylene;p-Xylylene
• CAS NO: 623-25-6
• Molecular Formula: C₈H₈Cl₂
• Molecular Weight: 175.06
• EINECS: 210-782-7
• Product Categories: Pharmaceutical Intermediates;Aryl;Building Blocks;C8;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 623-25-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 98-101 °C(lit.)
• Boiling Point: 254 °C(lit.)
• Flash Point: 254°C
• Appearance: White to light yellow/Crystalline Solid
• Density: 1,417 g/cm3
• Vapor Pressure: 0.541Pa at 25℃
• Refractive Index: 1.5544 (estimate)
• Storage Temp.: 2-8°C
• Solubility: methanol: 50 mg/mL, clear
• Water Solubility: hydrolysis
• BRN: 774706
• CAS DataBase Reference: alpha,alpha'-Dichloro-p-xylene(CAS DataBase Reference)
• NIST Chemistry Reference: alpha,alpha'-Dichloro-p-xylene(623-25-6)
• EPA Substance Registry System: alpha,alpha'-Dichloro-p-xylene(623-25-6)

Safety Data

• Hazard Codes: Xn,Xi,T+,C
• Statements: 22-36/38-36/37/38-26-50/53-34-36
• Safety Statements: 26-36/37-45-36/37/39-28A-27
• RIDADR: 3261
• WGK Germany: 3
• RTECS: ZE4100000
• F: 9-19-21
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 623-25-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

Different sources of media describe the Uses of 623-25-6 differently. You can refer to the following data:
1. α,α′-Dichloro-p-xylene is a monomer used in preparation of poly(p-phenylene vinylene(PPV) nanotubes and nanorods by chemical vapor deposition (CVD) polymerization method 1 . α,α′-Dichloro-p-xylene was used in a study to investigate the effect of CVD monomer selection and reaction conditions on the resulting PPV polymer layer composition and luminescence properties 2 .
2. p-Xylylene dichloride is a monomer used in preparation of poly(p-phenylene vinylene(PPV) nanotubes and nanorods by chemical vapor deposition (CVD) polymerization method. It was used in a study to investigate the effect of CVD monomer selection and reaction conditions on the resulting PPV polymer layer composition and luminescence properties.

General Description

α,α′-Dichloro-p-xylene undergoes phase transfer catalysed polycondensation with t-butylcyanoacetate to form carbon-carbon chain polymer.

Flammability and Explosibility

Notclassified

Purification Methods

Crystallise the xylene from *benzene and dry it under vacuum. [Beilstein 5 IV 967.]

Upstream product

• 128-09-6 N-chloro-succinimide 
• 106-42-3 para-xylene 
• 50-00-0 formaldehyd 
• 100-44-7 benzyl chloride 
• 542-88-1 bis(2-chloromethyl)ether 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 104-82-5 4-Methylbenzyl chloride 
• 108-88-3 toluene 
• 71-43-2 benzene 
• 513-53-1 1-methyl-1-propanethiol 
• 110866-77-8 p-phenylenedimethylene-1,1-bis(tetrahydrothiophen-1-ium)dichloride 
• 513-44-0 2-methylpropanethiol-1 
• 109-79-5 n-butanethiol 
• 75-66-1 2-methylpropan-2-thiol 

Downstream Products

• 56643-83-5 1,4-bis(imidazol-l-yl-methyl)benzene 
• 539-48-0 p-xylylidenediamine 
• 70364-29-3 3-[4-(2-ethoxycarbonyl-ethyl)-phenyl]-propionic acid ethyl ester 
• 19851-38-8 1,4-bis-(N,N-dimethylaminomethyl)benzene 
• 105207-39-4 N,N'-bis-(2-amino-ethyl)-p-xylylenediamine 
• 40828-00-0 N,N'-(1,4-phenylenebis(methylene))bis(N-ethylethanamine) 
• 15201-41-9 3,3'-(1,4-phenylene)dipropanenitrile 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 133333-36-5 1,4-bis(propoxymethyl)benzene 
• 17557-09-4 1,4-Bis-trimethylsilanylmethyl-benzene 
• 119505-44-1 3,3'-dimethoxy-4,4'-p-xylylenedioxy-di-benzoic acid dimethyl ester 
• 103643-18-1 N,N'-bis-(1,1,3,3-tetramethyl-butyl)-p-xylylenediamine 
• 109695-59-2 4,4'-p-xylylenedisulfonyl-di-butyric acid dimethyl ester 
• 102706-09-2 1,4-bis-benzoyloxymethyl-benzene 

Relevant articles and documents

p-Phenylenebismethylene: Characterization, calculation, and conversion to a conjugated bis-carbonyloxide [10]

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NMP-mediated chlorination of aliphatic alcohols with aryl sulfonyl chloride for the synthesis of alkyl chlorides

NMP-mediated chlorination of aliphatic alcohols has been developed for the synthesis of alkyl chlorides. This facile, efficient and practical approach used simple and readily available aryl sulfonyl chlorides as the chlorination reagent for the construction of C–Cl bond in good to excellent yields with mild conditions and broad substrate scope.

Method for preparing chlorohydrocarbons from alcohols by using aryl sulfonyl chloride as chlorination agent

The invention provides a method for preparing chlorohydrocarbons from alcohols by using aryl sulfonyl chloride as a chlorination agent. The method comprises the following steps: heating alcohols and aryl sulfonyl chloride in N,N-dialkyl substituted amide to react for 30 minutes, cooling the reaction product to room temperature, adding dichloromethane and water, carrying out extraction and skimming, washing the organic layer with saturated saline water, drying with anhydrous sodium sulfate, steaming to remove the solvent, and carrying out further separation and purification to obtain the chlorohydrocarbons. The method has the characteristics of cheap and accessible chlorination agent, simple technical process, short reaction time and the like, can obtain high reaction under the condition that the aryl sulfonyl chloride consumption is approximate to the stoichiometric quality, and can remove the reaction byproduct aryl sulfonic acid from the reaction mixture.