1367567-95-0

Basic information

• Product Name: Phenylephrine EP Impurity D
• Synonyms: Phenylephrine EP Impurity D;Phenylephrine Impurity D;3-[(1R)-2-[benzyl(methyl)amino]-1-hydroxyethyl]phenol;(R)-3-(2-(benzyl(methyl)amino)-1-hydroxyethyl)phenol hydrochloride;(αR)-3-Hydroxy-α-[[methyl(phenylmethyl)amino]methyl]-benzenemethanol
• CAS NO: 1367567-95-0
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.20502
• EINECS: 604-604-1
• Mol File: 1367567-95-0.mol

Chemical Properties

• Boiling Point: 437.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.170±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.76±0.10(Predicted)
• CAS DataBase Reference: Phenylephrine EP Impurity D(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylephrine EP Impurity D(1367567-95-0)
• EPA Substance Registry System: Phenylephrine EP Impurity D(1367567-95-0)

Safety Data

• Hazardous Substances Data: 1367567-95-0(Hazardous Substances Data)

Usage

Uses

Phenylephrine EP Impurity D is used as a pharmaceutical compound for its α-adrenergic agonist properties. It is particularly useful in the development and testing of medications that target α-adrenergic receptors, which play a crucial role in various physiological processes, including vasoconstriction, blood pressure regulation, and neurotransmission.
Used in Pharmaceutical Industry:
Phenylephrine EP Impurity D is used as a reference compound for the development and quality control of medications containing (R)-Phenylephrine. Its presence in the pharmaceutical industry is essential for ensuring the safety, efficacy, and purity of α-adrenergic agonist drugs.
Used in Research and Development:
Phenylephrine EP Impurity D is used as a research tool in the study of α-adrenergic receptors and their role in various physiological processes. It can help researchers understand the mechanisms of action, potential side effects, and therapeutic applications of α-adrenergic agonist drugs.
Used in Quality Control and Regulatory Compliance:
Phenylephrine EP Impurity D is used as a reference material in the quality control and regulatory compliance processes of pharmaceutical manufacturers. It helps ensure that the final drug products meet the required standards for purity, potency, and safety.

Upstream product

• 71786-67-9 2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanone hydrochloride 

Relevant articles and documents

Chiral amino-pyridine-phosphine tridentate ligand, manganese complex, and preparation method and application thereof

The invention discloses a chiral amino-pyridine-phosphine tridentate ligand, a manganese complex, and a preparation method and application thereof. The chiral amino-pyridine-phosphine tridentate ligand is shown as a formula II, and the manganese complex of the chiral amino-pyridine-phosphine tridentate ligand can be used for efficiently catalyzing and hydrogenating ketone compounds to prepare chiral alcohol compounds in a high enantioselectivity mode. The chiral amino-pyridine-phosphine tridentate ligand and the manganese complex are simple in synthesis process, good in stability, high in catalytic activity and mild in reaction conditions.

Lutidine-Based Chiral Pincer Manganese Catalysts for Enantioselective Hydrogenation of Ketones

A series of MnI complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex shows unprecedentedly high activities (up to 9800 TON; TON=turnover number), broad substrate scope (81 examples), good functional-group tolerance, and excellent enantioselectivities (85–98 % ee) in the hydrogenation of various ketones. These aspects are rare in earth-abundant metal catalyzed hydrogenations. The utility of the protocol have been demonstrated in the asymmetric synthesis of a variety of key intermediates for chiral drugs. Preliminary mechanistic investigations indicate that an outer-sphere mode of substrate–catalyst interactions probably dominates the catalysis.

Method for Ir/f-amphox high-efficiency synthesis of chiral α- C-amino alcohol by virtue of catalytic oxidation 1,2- of P-aminoketone by using one-aminoketone

The invention discloses a method for efficiently synthesizing chiral 1,2-amino alcohol by catalyzing alpha-aminoketone through Ir/f-amphox. A ligand f-amphox used by the method can be more easily synthesized; the reaction has the characteristics of enanti

A feasibility study on the synthesis of phenylephrine via ruthenium-catalyzed homogeneous asymmetric hydrogenation

We report a feasibility study on a new route to (R)-phenylephrine, based on the ruthenium-catalyzed asymmetric hydrogenation of an aminoketone precursor. The direct and fast asymmetric reduction of aminoketones or their hydrochloride salts is achievable at low catalyst loadings (molar substrate to catalyst ratio, S/C, >25,000/1, TOF up to 25,000 h-1) with high enantioselectivity (>95% ee), without the need for N-protection nor isolation of the free base prior to reaction.

Method for preparing of L-phenylephrine hydrochloride

The present invention relates to an improved process for preparing L-phenylephrine hydrochloride 3 on an industrial scale by asymmetric hydrogenation as the key step and a special sequence of subsequent steps, using [Rh(COD)Cl]2 as catalyst and a chiral, two-pronged phosphine ligand such as (2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine as the catalyst system.