136860-53-2

Basic information

• Product Name: Carbamic acid, tricyclo[3.3.1.13,7]dec-1-yl-, phenylmethyl ester (9CI)
• Synonyms: Carbamic acid, tricyclo[3.3.1.13,7]dec-1-yl-, phenylmethyl ester (9CI)
• CAS NO: 136860-53-2
• Molecular Formula: C₁₈H₂₃NO₂
• Molecular Weight: 285.38072
• Product Categories: N-CBZ
• Mol File: 136860-53-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, tricyclo[3.3.1.13,7]dec-1-yl-, phenylmethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, tricyclo[3.3.1.13,7]dec-1-yl-, phenylmethyl ester (9CI)(136860-53-2)
• EPA Substance Registry System: Carbamic acid, tricyclo[3.3.1.13,7]dec-1-yl-, phenylmethyl ester (9CI)(136860-53-2)

Safety Data

• Hazardous Substances Data: 136860-53-2(Hazardous Substances Data)

Upstream product

• 65839-12-5 N-(adamantan-1-yl) S-ethyl carbamothioate 
• 100-51-6 benzyl alcohol 
• 219844-58-3 N-(t-butyloxycarbonyl)-N-(methanesulfonyloxy)-1-adamantanecarboxamide 
• 768-94-5 1-Adamantanamine 
• 501-53-1 benzyl chloroformate 
• 621-84-1 O-benzyl carbamate 
• 768-95-6 1-adamanthanol 
• 71189-14-5 (Tricyclo<3.3.1.1^3,7>dec-2-yl)isocyanat 

Relevant articles and documents

N-Substituted S-Alkyl Carbamothioates in the Synthesis of Nitrogen-containing Functional Derivatives of the Adamantane Series

Abstract: A series of new asymmetric ureas, urethanes, and other derivatives of the framework structure have been synthesized by the reactions of adamantan-1-yl isocyanate generated in situ by the thermolysis of carbamothioates with nitrogen-containing nucleophiles and alcohols.

Aluminum triflate as a powerful catalyst for direct amination of alcohols, including electron-withdrawing group-substituted benzhydrols

Direct aminations of allylic alcohols, benzylic alcohols, and benzhydrols with electron-withdrawing (F, Br, I, NO2, or CN) substituents were efficiently catalyzed by aluminum triflate [Al(OTf)3] to afford the corresponding biarylamines in high yield, and the dibromo-substituted product was further transformed into letrozole. Copyright

Amberlyst-15 catalyzed Cbz protection of amines under solvent-free conditions

Amberlyst-15 can effectively catalyze Cbz protection of aliphatic and aromatic amines within 10-15 min under solvent-free conditions. The catalyst can be used repeatedly without loss of activity, and the reaction requires no workup and gives excellent yields. Taylor & Francis Group, LLC.

An excellent method for Cbz-protection of amines

Cbz-protection of aliphatic and aromatic amines can be accomplished with benzylchloroformate using a catalytic amount of dodecatungstophosphoric acid hydrate (0.05 equiv). The reaction is simple, fast, does not require aqueous work-up and gives excellent yields.