- Zinc(II) complexes with dithiocarbamato derivatives: Structural characterisation and biological assays on cancerous cell lines
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Zinc is one of the most important trace elements in the body and it is essential as a cofactor for the structure and function of a number of cellular molecules including enzymes, transcription factors, cellular signalling proteins and DNA repair enzymes. On the other hand, recent studies have shown that zinc could play a role both in the development of various cancers and in the induction of apoptosis in some cell types, however, no established common relationships of zinc with cancer development and progression have been identified. To date, in our research group different metal-dithiocarbamato complexes have been designed that were expected to resemble the main features of cisplatin together with higher activity, improved selectivity and bioavailability, and lower side-effects. On the basis of the obtained encouraging achievements with other metals (such as gold and copper) we have decided to enlarge the studies to the complexes of zinc(II) using the same ligands. Hereby, we report the results on the synthesis and characterisation of ZnL2 complexes with five different dithiocarbamato derivatives, such as dimethyl-(DMDT), pyrrolidine-(PyDT), methyl-(MSDT), ethyl-(ESDT) and tert-butyl-(TSDT) sarcosinedithiocarbamate. All the obtained compounds have fully been characterised by means of several spectroscopic techniques. In addition, the crystal structure of [Zn(MSDT)2]2 dinuclear complex is also reported. In order to evaluate the in vitro cytotoxic properties, some biological assays have been carried out on a panel of human tumour cell lines sensible and resistant to cisplatin. Some of the tested compounds show cytotoxicity levels comparable or even greater than the reference drug (cisplatin).
- Nagy, Eszter Márta,Sitran, Sergio,Montopoli, Monica,Favaro, Monica,Marchiò, Luciano,Caparrotta, Laura,Fregona, Dolores
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- Thermochemical parameters and calculations ab-initio of the bisdimethyldithiocarbamate zinc(ii) complex
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The standard molar enthalpy of formation of crystalline bisdimethyldithiocarbamate zinc(II) complex, Zn[S2CN(CH 3)2]2 was determined through reaction-solution calorimetry in acetone, at 298 K. Using the standard
- Botelho,Souza,Gondim,Athayde-Filho,Dunstan,Pinheiro,Longo,Carvalho
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- Gas-phase electron diffraction study of bis(dimethyldithiocarbamato)copper(II), [Cu(S2CNMe2)2], and bis(dimethyldithiocarbamato)zinc(II), [Zn(S2CNMe2)2]
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The molecular structures of [Cu(S2CNMe2)2] and [Zn(S2CNMe2)2] have been studied by gas-phase electron diffraction. Both compounds are monomeric in the gas phase with the metal atoms being bound to two chelating [S2CNMe2] groups (rg(Cu-S) = 2.284 (9) ?; rg(Zn-S) = 2.348 (8) ?). The major difference between the two structures is in the geometry of the MS4 fragments, that of the copper compounds being pseudo square planar (D2h) while that of the zinc compound is pseudotetrahedral (D2d). The reason for the difference is attributed to the availability in the copper(II) compound of crystal field stabilization energy that is greater than the repulsive energy of the steric interactions imposed by the metal adopting a coordination sphere of D2h symmetry. Selected bond lengths and angles in the [S2CNMe2] groups are as follows (the data for the copper compound are quoted first with those for the zinc species being in brackets): rg(C-S) = 1.716 (10) ? [1.727 (10) ?]; rg(C=N) = 1.334 (18) ? [1.351 (17) ?]; rg(C-N) = 1.476 (18) ? [1.479 (17) ?]; ∠αS-M-S(chelate angle) = 78.78 (69)° [79.68 (59)°]; ∠αC=N-C = 124.9 (1.3)° [122.5 (1.2)°].
- Hagen, Kolbj?rn,Holwill, Catherine J.,Rice, David A.
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p. 3239 - 3242
(2008/10/08)
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- THE DIRECT ELECTROCHEMICAL SYNTHESIS OF DIALKYLDITHIOCARBAMATE AND DIETHYLDITHIOPHOSPHATE COMPLEXES OF MAIN GROUP AND TRANSITION METALS
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Dialkyldithiocarbamate derivatives (R2NCS2)nM of a number of metals (M=Fe, Co, Ni, Cu, Ag, Zn, Cd, In, Tl) have been synthesised in good yield by electrochemical oxidation of appropriate sacrificial anodes in non-aqueous solutions of either the corresponding tetraalkylthiuran disulphide (R2NCS2)2 (R=Me, Et) or a mixture of carbon disulphide plus the secondary amine R2NH (R=Et, i-Pr; R2NH=piperidine).Similar experiments with solutions of (EtO)2P(S)SH (=HL) gave MLn* derivatives (M=Fe, Co, Ni, Cu, Ag, Au, Zn, Cd, Hg, Ga, In, Tl) while in the presence of HL+1,10-phenanthroline, MLn.phen derivatives were obtained for M=V, Mn, Fe, Co, Zn, and Ga.
- Geloso, Corrado,Kumar, Rajesh,Lopez-Grado, Jaime Romero,Tuck, Dennis G.
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p. 928 - 932
(2007/10/02)
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