137-44-0

Basic information

• Product Name: 1,3,5PYRAZOLONE
• Synonyms: 5-PYRAZOLONE;1,3,5PYRAZOLONE;2-Pyrazolin-5-one;1H-pyrazol-5(4H)-one;3H-Pyrazol-3-one, 2,4-dihydro-;NSC 243823;2,4-Dihydro-pyrazol-3-one
• CAS NO: 137-44-0
• Molecular Formula: C₃H₄N₂O
• Molecular Weight: 82.06078
• Mol File: 137-44-0.mol

Chemical Properties

• Melting Point: 268℃
• Boiling Point: 143-144℃ (0.3 Torr)
• Appearance: /
• Density: 1.44 g/cm³
• Refractive Index: 1.63
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.06±0.20(Predicted)
• CAS DataBase Reference: 1,3,5PYRAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5PYRAZOLONE(137-44-0)
• EPA Substance Registry System: 1,3,5PYRAZOLONE(137-44-0)

Safety Data

• Hazardous Substances Data: 137-44-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,3,5-Pyrazolone is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical properties and ability to form complexes with metal ions.
Used in Agrochemical Industry:
1,3,5-Pyrazolone is used as a building block for the synthesis of agrochemicals, contributing to the development of effective and safe pesticides and other agricultural chemicals.
Used in Dye Industry:
1,3,5-Pyrazolone is used as a building block for the synthesis of dyes, providing a wide range of colors and properties for various applications.
Used in Organic Synthesis:
1,3,5-Pyrazolone is used as a reagent in organic synthesis reactions, particularly in the formation of heterocyclic compounds, due to its ability to form complexes with metal ions and participate in various chemical reactions.
Used in Research and Development:
1,3,5-Pyrazolone is used in research and development for studying its potential pharmacological properties, such as anti-inflammatory and antitumor activities, which could lead to the discovery of new therapeutic agents.

InChI:InChI=1/C3H4N2O/c6-3-1-2-4-5-3/h2H,1H2,(H,5,6)

Upstream product

• 63857-17-0 methyl 3-oxopropionate 

Downstream Products

• 17822-51-4 1-benzylidene-3-oxo-1-pyrazolidinium-2-ide 
• 1929-18-6 bis-(2-amino-benzylidene)-hydrazine 
• 89522-16-7 3-{[1-(2-Amino-phenyl)-meth-(Z)-ylidene]-hydrazonomethyl}-1H-quinolin-2-one 
• 10234-66-9 2,4-dihydro-2-methyl-3H-pyrazol-3-one 
• 1220111-65-8 (Z)-4-(2-(2-chlorophenyl)hydrazono)-1H-pyrazol-5(4H)-one 

Relevant articles and documents

3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3β

A series of 3-aryl-4-(arylhydrazono)-1H-pyrazol-5-one inhibitors of GSK3β was developed from a low molecular weight, highly ligand efficient screening hit 1. Hit-to-lead optimization led to a number of highly potent inhibitors, while maintaining the high ligand efficiency of the screening hit.

Method for preparing 2-pyrazolin-5-ones from 1,2,4-oxadiazoles

A method for preparing 2-pyrazolin-5-ones from 1,2,4-oxadiazoles is described. The method comprises forming a liquid reaction system of a base catalyst and a 1,2,4-oxadiazole in an organic liquid reaction medium and heating the reaction system to a temperature sufficient to cause the 1,2,4-oxadiazole to be rearranged to a 2-pyrazolin-5-one.