10234-66-9

Basic information

• Product Name: 1-Methyl-1H-pyrazol-5(4H)-one
• Synonyms: 1-Methyl-1H-pyrazol-5(4H)-one;1-Methyl-5-pyrazolone;2-Methyl-2,4-dihydropyrazol-3-one;1-Methyl-2-pyrazolin-5-one;1-Methyl-1H-pyrazol-5(4H)
• CAS NO: 10234-66-9
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.10324
• Mol File: 10234-66-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-1H-pyrazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazol-5(4H)-one(10234-66-9)
• EPA Substance Registry System: 1-Methyl-1H-pyrazol-5(4H)-one(10234-66-9)

Safety Data

• Hazardous Substances Data: 10234-66-9(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-pyrazol-5(4H)-one, also known as N-methylpyrazolone, is a chemical compound with the molecular formula C4H6N2O. It is a cyclic ketone and a pyrazole derivative that is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. It has a wide range of applications, including as a reagent in organic chemistry reactions, as a precursor for the manufacture of various drugs, and as an intermediate in the production of agricultural chemicals. It is a white to off-white crystalline solid with a slightly bitter taste, and it is soluble in water and organic solvents. 1-Methyl-1H-pyrazol-5(4H)-one is considered to be relatively stable and has low toxicity, making it a valuable and versatile compound in the chemical industry.

Upstream product

• 57707-21-8 1-methyl-2-pyrazolinone 
• 54367-66-7 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid 
• 67-56-1 methanol 
• 137-44-0 2-pyrazolin-5-one 

Downstream Products

• 1169757-10-1 (1,6-dimethyl-4-methylthio-1H-pyrazolo[3,4-b]pyridin-5-yl)(phenyl)methanone 
• 1169757-19-0 1,5-dimethyl-4-methylthio-6-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 1169757-18-9 C₁₇H₁₇N₃OS 
• 1159186-94-3 5-iodo-2-(1-methyl-1H-pyrazol-5-yloxy)benzonitrile 
• 117007-77-9 5-chloro-1-methyl-1H-pyrazole-4-carbaldehyde 
• 89522-17-8 C₂₂H₂₂N₆O₂ 
• 109883-05-8 (5-Hydroxy-1-methyl-1H-pyrazol-4-yl)-phenyl-methanone 

Relevant articles and documents

Method for producing 1 substituted 5-chloro-4 methly pyrazoles

The present invention relates to a process for preparing 1-substituted 5-chloro-4-methylpyrazoles of the general formula I with the meaning for R stated in claim 1, in which a 4-methylpyrazole of the formula II is reacted with chlorine, the resulting mixture of monochlorinated and dichlorinated product is fractionated by distillation, and subsequently the dichlorinated compound is dehalogenated to compound II and returned to the reaction with chlorine.

Selective N-methylation of pyrazolone with methanol by use of ZrO2 catalyst in the liquid phase

Selective methylation of pyrazolone to 1-methylpyrazolone was investigated with ZrO2, which is a representative metal oxide with amphoteric character. The high selectivity up to ~7% was obtained at 503 K. Mechanism is proposed in view of weak acidic-moderately basic pair sites of ZrO2.

REGIOSELECTIVE NUCLEOPHILIC SUBSTITUTION IN ACTIVATED 1-AMINOPYRAZOLIUM CATIONS: A FACILE SYNTHESIS OF 5-SUBSTITUTED 1-METHYLPYRAZOLES

5-Substituted 1-methylpyrazoles were easily obtained in good yields by the attack of nucleophiles (NaCN, H2O, EtSH, pyrazole, imidazole) to 2,6-dimethyl-1-(2-methylpyrazol-1-io)-4-phenylpyridinium bistetrafluoroborate (1b), without significant formation o