10234-66-9

Basic information

• Product Name: 1-Methyl-1H-pyrazol-5(4H)-one
• Synonyms: 1-Methyl-1H-pyrazol-5(4H)-one;1-Methyl-5-pyrazolone;2-Methyl-2,4-dihydropyrazol-3-one;1-Methyl-2-pyrazolin-5-one;1-Methyl-1H-pyrazol-5(4H)
• CAS NO: 10234-66-9
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.10324
• Mol File: 10234-66-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-1H-pyrazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-pyrazol-5(4H)-one(10234-66-9)
• EPA Substance Registry System: 1-Methyl-1H-pyrazol-5(4H)-one(10234-66-9)

Safety Data

• Hazardous Substances Data: 10234-66-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-1H-pyrazol-5(4H)-one is used as a key intermediate for the synthesis of various drugs, contributing to the development of new medications and therapeutic agents. Its unique chemical structure allows it to be a part of the molecular framework of several pharmaceutical compounds, enhancing their efficacy and pharmacological properties.
Used in Organic Chemistry:
As a reagent in organic chemistry reactions, 1-Methyl-1H-pyrazol-5(4H)-one facilitates a range of chemical transformations, enabling the synthesis of complex organic molecules. Its presence in these reactions can improve the yield and selectivity of the desired products, making it an essential component in the field of organic synthesis.
Used in Agricultural Chemicals Production:
1-Methyl-1H-pyrazol-5(4H)-one serves as a precursor in the manufacture of agricultural chemicals, including pesticides and herbicides. Its incorporation into these products helps to improve their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and agricultural productivity.

Upstream product

• 67-56-1 methanol 
• 137-44-0 2-pyrazolin-5-one 
• 54367-66-7 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid 
• 57707-21-8 1-methyl-2-pyrazolinone 

Downstream Products

• 117007-77-9 5-chloro-1-methyl-1H-pyrazole-4-carbaldehyde 
• 1169757-10-1 (1,6-dimethyl-4-methylthio-1H-pyrazolo[3,4-b]pyridin-5-yl)(phenyl)methanone 
• 1169757-19-0 1,5-dimethyl-4-methylthio-6-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 1169757-18-9 C₁₇H₁₇N₃OS 
• 1159186-94-3 5-iodo-2-(1-methyl-1H-pyrazol-5-yloxy)benzonitrile 
• 89522-17-8 C₂₂H₂₂N₆O₂ 
• 109883-05-8 (5-Hydroxy-1-methyl-1H-pyrazol-4-yl)-phenyl-methanone 

Relevant articles and documents

Method for producing 1 substituted 5-chloro-4 methly pyrazoles

The present invention relates to a process for preparing 1-substituted 5-chloro-4-methylpyrazoles of the general formula I with the meaning for R stated in claim 1, in which a 4-methylpyrazole of the formula II is reacted with chlorine, the resulting mixture of monochlorinated and dichlorinated product is fractionated by distillation, and subsequently the dichlorinated compound is dehalogenated to compound II and returned to the reaction with chlorine.

Method for producing N-substituted 2-pyrazoline-5-one

The present invention relates to a process for preparing N-substituted 2-pyrazolin-5-ones of the formula I where R has the meaning given in claim 1, which comprises reacting a compound of the formula II where R, X and Y have the meanings given in claim 1, at elevated temperature with a molar excess of alkali metal hydroxide in an aqueous reaction medium and then adjusting the pH to pH≦6 by adding an acid.

Selective N-methylation of pyrazolone with methanol by use of ZrO2 catalyst in the liquid phase

Selective methylation of pyrazolone to 1-methylpyrazolone was investigated with ZrO2, which is a representative metal oxide with amphoteric character. The high selectivity up to ~7% was obtained at 503 K. Mechanism is proposed in view of weak acidic-moderately basic pair sites of ZrO2.

Intramolecular Hetero-Diels-Alder Reaction of Alkylidene- and Benzylidenepyrazolones and Benzylideneisoxazolones. Investigations toward the Conformation of the Transition State

Stereochemical aspects of the intramolecular hetero-Diels-Alder reaction of hetero dienes are studied.Knoevenagel condensation of aromatic aldehydes 1, 12, 15,, and 21 with pyrazolones 8a-h and isoxazolone 17 gave the corresponding hetero dienes, e.g.,9a-

REGIOSELECTIVE NUCLEOPHILIC SUBSTITUTION IN ACTIVATED 1-AMINOPYRAZOLIUM CATIONS: A FACILE SYNTHESIS OF 5-SUBSTITUTED 1-METHYLPYRAZOLES

5-Substituted 1-methylpyrazoles were easily obtained in good yields by the attack of nucleophiles (NaCN, H2O, EtSH, pyrazole, imidazole) to 2,6-dimethyl-1-(2-methylpyrazol-1-io)-4-phenylpyridinium bistetrafluoroborate (1b), without significant formation o