- Enantioselective synthesis of 2,2-disubstituted tetrahydrofurans: Palladium-catalyzed [3+2] cycloadditions of trimethylenemethane with ketones
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O rings: An approach to the title compounds has been developed utilizing a cycloaddition of trimethylenemethane with aryl ketones. The products are formed in up to a 96 % yield with 95 % ee. The reaction is catalyzed by palladium in the presence of L1, which possesses a stereogenic phosphorus atom, and only a single epimer at the phosphorus atom yields the active catalyst. Cp=cyclopentadiene, TMS=trimethylsilyl. Copyright
- Trost, Barry M.,Bringley, Dustin A.
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- ANTIMYCOTIC TRIAZOLE COMPOUND
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The invention relates to Compound (I), which is 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)-N-(4-fluorophenyl)benzamide, or a pharmaceutically acceptable salt thereof, usefu
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Page/Page column 3; 13
(2017/07/08)
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- ANTIMYCOTIC COMPOUND
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This invention relates to a compound, as defined in the specification, useful in the treatment of mycoses, compositions containing it and its use in therapy.
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Page/Page column 16
(2016/06/28)
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