1370190-85-4 Usage
General Description
(R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole is a chemical compound that belongs to the class of triazoles. It is a potent antifungal agent and is commonly used in the treatment of fungal infections. (R)-1-((2-(2,4-difluorophenyl)-4-methylenetetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole works by inhibiting the synthesis of ergosterol, a crucial component of the fungal cell membrane, thereby disrupting the membrane integrity and leading to the death of the fungal cells. The presence of difluorophenyl and tetrahydrofuran moieties in its structure contributes to its antifungal activity, making it an effective therapeutic agent against a wide range of fungal pathogens. Additionally, this compound has shown potential for use in agricultural applications as a fungicide to protect crops from fungal diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1370190-85-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,0,1,9 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1370190-85:
(9*1)+(8*3)+(7*7)+(6*0)+(5*1)+(4*9)+(3*0)+(2*8)+(1*5)=144
144 % 10 = 4
So 1370190-85-4 is a valid CAS Registry Number.
1370190-85-4Relevant articles and documents
Enantioselective synthesis of 2,2-disubstituted tetrahydrofurans: Palladium-catalyzed [3+2] cycloadditions of trimethylenemethane with ketones
Trost, Barry M.,Bringley, Dustin A.
, p. 4466 - 4469 (2013)
O rings: An approach to the title compounds has been developed utilizing a cycloaddition of trimethylenemethane with aryl ketones. The products are formed in up to a 96 % yield with 95 % ee. The reaction is catalyzed by palladium in the presence of L1, which possesses a stereogenic phosphorus atom, and only a single epimer at the phosphorus atom yields the active catalyst. Cp=cyclopentadiene, TMS=trimethylsilyl. Copyright
ANTIMYCOTIC COMPOUND
-
Page/Page column 16, (2016/06/28)
This invention relates to a compound, as defined in the specification, useful in the treatment of mycoses, compositions containing it and its use in therapy.
