13712-78-2

Basic information

• Product Name: 7-METHYLGRAMINE
• Synonyms: 3-(DIMETHYLAMINOMETHYL)-7-METHYLINDOLE;7-METHYLGRAMINE;3-((dimethylamino)methyl)-7-methyl-indol;Indole, 3-((dimethylamino)methyl)-7-methyl-
• CAS NO: 13712-78-2
• Molecular Formula: C12H16N2
• Molecular Weight: 188.27
• Product Categories: Indoles and derivatives
• Mol File: 13712-78-2.mol

Chemical Properties

• Boiling Point: 306.5 °C at 760 mmHg
• Flash Point: 139.2 °C
• Appearance: /
• Density: 1.077 g/cm³
• Vapor Pressure: 0.000768mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHYLGRAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYLGRAMINE(13712-78-2)
• EPA Substance Registry System: 7-METHYLGRAMINE(13712-78-2)

Safety Data

• Hazardous Substances Data: 13712-78-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Methylgramine is used as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's due to its inhibitory effects on acetylcholinesterase, which can help improve cognitive function and slow down disease progression.
Used in Drug Development:
7-Methylgramine serves as a lead compound for the development of novel therapeutic agents targeting various medical conditions, given its diverse pharmacological properties, including anti-inflammatory, antioxidant, and neuroprotective effects.
Used in Neuroprotection:
7-Methylgramine is used as a neuroprotective agent to safeguard neurons from damage and degeneration, potentially contributing to the treatment and prevention of neurodegenerative diseases.
Used in Anti-inflammatory Applications:
7-Methylgramine is utilized as an anti-inflammatory agent to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Antioxidant Therapy:
7-Methylgramine is employed as an antioxidant to combat oxidative stress and protect cells from damage caused by reactive oxygen species, which can contribute to various diseases and aging processes.
Further research is required to fully elucidate the pharmacological properties of 7-Methylgramine and explore its potential clinical applications across different medical fields.

InChI:InChI=1/C12H16N2/c1-9-5-4-6-11-10(8-14(2)3)7-13-12(9)11/h4-7,13H,8H2,1-3H3

Upstream product

• 933-67-5 7-methyl-1H-indole 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 858232-97-0 2-(7-methyl-1H-indol-3-yl)acetonitrile 

Relevant articles and documents

I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines

The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives.

Rhodium-Catalyzed Enantioselective Cyclization of 3-Allenyl-indoles: Access to Functionalized Tetrahydrocarbazoles

A highly selective rhodium-catalyzed cyclization of tethered 3-allenylindoles is reported. In a smooth reaction, 1-vinyltetrahydrocarbazoles are obtained in excellent yields and enantioselectivities. Aside from a great functional group tolerance, this method requires neither the Schlenk technique nor the use of anhydrous solvents. Preliminary mechanistic investigations proved that the reaction proceeds via an intermediary formed spiroindolenine which rapidly undergoes an acid-catalyzed stereospecific migration.

Rhodium-Catalyzed Diastereo- And Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines

A highly selective rhodium-catalyzed tandem spirocyclization/reduction of 3-allenylindoles is reported. By employing a Hantzsch ester as reductant, vinylic spiroindolines are obtained in excellent yields as well as diastereo- and enantioselectivity. In addition, the reaction's synthetic utility is highlighted by broad functional group compatibility and exemplified by a gram scale reaction with subsequent assorted transformations.

Enantioselective gold-catalyzed allylic alkylation of indoles with ALcohols: An efficient route to functionalized tetrahydrocarbazoles

[Chemical equation presented] Breaking the taboo: The direct use of allylic alcohols in catalytic and enantioselective Friedel-Crafts alkylation is described for the first time In the presence of chiral gold complexes. This intramolecular Friedel-Crafts reaction was used to prepare a broad range of functionalized tetrahydrocarbazoles (see scheme; X=Me, F, Br, Cl, OMe; R=Me, Et, tBu; R′=H, Me).