- Heterocyclic Adenosine Receptor Antagonists
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Heterocyclic compounds useful as antagonists of adenosine receptors, and methods of treatment of diseases using antagonists of adenosine receptors are disclosed herein. Also disclosed herein are pharmaceutical compositions and methods of administration of
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Paragraph 0221-0223
(2021/09/26)
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- Alkali α-MnO2/Na: XMnO2 collaboratively catalyzed ammoxidation-Pinner tandem reaction of aldehydes
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The tandem reaction is a growing field to yield important advances toward green and sustainable chemistry. Herein, we report a bifunctional manganese oxide catalyst with an interface binding redox phase (α-MnO2) and a basic phase (NaxMnO2). The molar ratio of NaOH/Mn plays a great role in the formation of α-MnO2/NaxMnO2. The sodium cation is essential for the formation of a basic NaxMnO2 phase while the potassium cation promotes the formation of a redox-active α-MnO2 phase. The interface structure of α-MnO2/NaxMnO2 geometrically favors the ammoxidation-Pinner tandem reaction to synthesize imidates in a 58-96% yield from aldehydes. Thus a phase collaborative effect is observed. In the ammoxidation process, the redox cycle of MnIV/MnIII is involved and the lattice oxygen in the α-MnO2 phase acts as an active oxygen species. The O-H in methanol is activated and dissociated on the basic sites of NaxMnO2 to the adsorbed methoxyl species to facilitate the Pinner synthesis. This approach bypasses the conventional synthesis of imidates, which suffer from harsh reaction conditions and the requirement for multiple steps.
- Jia, Xiuquan,Ma, Jiping,Wang, Min,Li, Xiaofang,Gao, Jin,Xu, Jie
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p. 7429 - 7436
(2016/10/21)
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- Direct oxidative conversion of aldehydes to nitriles using IBX in aqueous ammonia
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A mild, simple, chemoselective and high yielding procedure for the direct oxidative conversion of aldehydes to nitriles has been developed using IBX in aqueous ammonia.
- Arote, Nitin D.,Bhalerao, Dinesh S.,Akamanchi, Krishnacharya G.
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p. 3651 - 3653
(2008/02/03)
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- S,S-dimethyl dithiocarbonate: A useful reagent for efficient conversion of aldoximes to nitriles
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Dimethyl dithiocarbonate (DMDTC) has been shown to be an efficient dehydrating agent for a range of oximes derived from aliphatic, aromatic and heteroaromatic aldehydes yielding the corresponding nitriles in high yields.
- Khan, Taukeer Ahmad,Peruncheralathan, Saravanan,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
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p. 2019 - 2021
(2007/10/03)
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- A simple method for the synthesis of 5-substituted 2-cyanofurans
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A new method based on the Schmidt reaction was developed for the production of 5-R-2-cyanofurans from 5-R-furfurals.
- Pavlov
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p. 524 - 529
(2007/10/03)
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- Elimination reactions of (Z)-thiophene- and (Z)-furan-2-carbaldehyde O- benzoyloximes. Effect of β-aryl group upon the nitrile-forming anti transition state
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Elimination reactions of (Z)-thiophene- and (Z)-furan-2-carbaldehyde O- benzoyloximes 1 and 2 with DBU in MeCN have been investigated kinetically. The reactions are second order and exhibit substantial values of Hammett ρ and k(H)/k(D) values, and an E2 m
- Cho, Bong Rae,Cho, Nam Soon,Song, Sang Hun,Lee, Sang Kook
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p. 8304 - 8309
(2007/10/03)
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- SYNTHESIS OF 5-SUBSTITUTED CYANOFURANS AND THEIR REACTION WITH HYDRAZINE
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Based on the Schmidt reaction, a new method has been developed for the preparation of nitriles in furan series from the corresponding furfural derivatives.Depending on conditions, the reaction of 5-substituted cyanofurans with hydrazine leads to amidrazones, N-aminotriazoles, or 1,2,4,5-dihydrotetrazines.
- Pavlov, P. A.,Kul'nevich, V. G.
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p. 140 - 145
(2007/10/02)
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- A Useful Method for the Conversion of Aldehyde Oximes into Nitriles Using 1,1'-Oxalyldiimidazole
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Under neutral conditions, aliphatic, alicyclic, aromatic, and heteroaromatic aldehyde oximes (3) react with 1,1'-oxalyldiimidazole (2) in an appropriate solvent such as benzene, acetonitrile, chloroform, or tetrahydrofuran at 65-70 degC within 1 h to give the corresponding nitriles (4) in good yield.Keywords --- dehydration; 1,1'-carbonyldiimidazole; 1,1'-oxalyldiimidazole; oxime; nitrile
- Kitagawa, Tokujiro,Sasaki, Hideaki,Ono, Noriyuki
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p. 4014 - 4016
(2007/10/02)
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