cas 151-50-8, Potassium cyanide | Articles data

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Synthesis of an α-amino nitrile and a bis α-amino nitrile derivative of thiadiazole: Reaction mechanism
The first nucleophilic addition of an inorganic nucleophile (cyanide) to the activated, rigid, α-diazomethine groups of a 1,2,5-thiadiazole 1,1-dioxide is reported here. An α-amino nitrile and a bis a-amino nitrile derivatives were obtained in good yields (62 and 98%, respectively) and characterized by spectroscopic, analytical, and single crystal X-ray diffraction techniques. The course of the reaction, followed by cyclic voltammetry (CV), showed that cyanide adds to only one of the two C=N double bonds of the thiadiazole, forming an anion from which an N-methyl derivative was obtained. Adequate concentrations of cyanide and methyl iodide (MeI) produced directly the bis a-amino nitrile derivative. Copyright
Mirifico, Maria Virginia,Caram, Jose Alberto,Piro, Oscar Enrique,Vasini, Enrique Julio
p. 1081 - 1087
(2007)
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