- Preparation method of 4''-alkyl-2, 4, 3'-trifluoro-terphenyl liquid crystal monomer
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The invention relates to the field of liquid crystal display, in particular to a preparation method of a 4''-alkyl-2, 4, 3'-trifluoro-terphenyl liquid crystal monomer for liquid crystal display. The preparation method comprises the following steps: taking 3-fluoro-4-chlorobromobenzene as a raw material, and preparing 3-fluoro-4-chlorophenylboronic acid through Grignard reaction; carrying out Suzuki coupling reaction on the 3-fluoro-4-chlorophenylboronic acid and 2, 4'-difluorobromobenzene to obtain a key intermediate 4'-chloro-2, 4, 3'-trifluoro-biphenyl; and carrying out Suzuki coupling reaction on the intermediate and 4-alkylphenylboronic acid to a to obtain the liquid crystal monomer. The synthesis route adopts cheap raw materials, a final product is prepared through conventional reactions, the production cost is low, large-scale production is facilitated, and the preparation method has a very high application prospect.
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Paragraph 0012; 0013
(2020/06/30)
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- QUINAZOLINONE DERIVATIVES USEFUL AS ANTI-HYPERALGESIC AGENTS
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The present invention relates to quinazolinones of formula (I) wherein R1 is hal; a); b); or c); X is N or CR8; R2 is hal; nitro; C1-C6alkylcarbonyl; C1-C6alkyl or C3-C6cycloalkyl; R3 is C1-C6alkyl; C1-C6alkoxy or amino; and wherein the further radicals have the meanings as defined in the specification, which compounds exhibit human vanilloid antagonistic activity; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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