Welcome to LookChem.com Sign In|Join Free

CAS

  • or
5-METHYL-4-PHENYL-2(3H)-THIAZOLONE HYDRAZONE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

137506-14-0 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 137506-14-0 Structure
  • Basic information

    1. Product Name: 5-METHYL-4-PHENYL-2(3H)-THIAZOLONE HYDRAZONE
    2. Synonyms: 5-METHYL-4-PHENYL-2(3H)-THIAZOLONE HYDRAZONE
    3. CAS NO:137506-14-0
    4. Molecular Formula: C10H11N3S
    5. Molecular Weight: 205.28
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 137506-14-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-METHYL-4-PHENYL-2(3H)-THIAZOLONE HYDRAZONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-METHYL-4-PHENYL-2(3H)-THIAZOLONE HYDRAZONE(137506-14-0)
    11. EPA Substance Registry System: 5-METHYL-4-PHENYL-2(3H)-THIAZOLONE HYDRAZONE(137506-14-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 137506-14-0(Hazardous Substances Data)

137506-14-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 137506-14-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,5,0 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 137506-14:
(8*1)+(7*3)+(6*7)+(5*5)+(4*0)+(3*6)+(2*1)+(1*4)=120
120 % 10 = 0
So 137506-14-0 is a valid CAS Registry Number.

137506-14-0Relevant articles and documents

Structure-based design of potent human dihydroorotate dehydrogenase inhibitors as anticancer agents

Song, Wenlin,Li, Shiliang,Tong, Yi,Wang, Jiawei,Quan, Lina,Chen, Zhuo,Zhao, Zhenjiang,Xu, Yufang,Zhu, Lili,Qian, Xuhong,Li, Honglin

, p. 1441 - 1448 (2016/07/21)

It has been proven that inhibiting human dihydroorotate dehydrogenase (hDHODH) restricts the growth of rapidly proliferating cells, thus hDHODH can be developed as a promising target for the treatment of immunological disease and cancer. Here, a succession of substituted hydrazino-thiazole derivatives were designed, synthesized, and biologically evaluated through structure-based optimization, of which compound 22 was the most potent inhibitor of hDHODH with an IC50 value of 1.8 nM. Furthermore, 22 exhibited much better antiproliferative activity than brequinar, both in HCT-116 and BxPC-3 cancer cell lines. Flow cytometry analysis revealed that 22 induced S phase cell cycle arrest and promoted induction of apoptosis. All results established a proof that blocking the pyrimidine de novo synthesis pathway by inhibiting the rate-limiting enzyme hDHODH is an attractive therapy for cancer.

ARYLSUBSTITUTED THIAZOLOTRIAZOLES AND THIAZOLOIMIDAZOLES

-

Page/Page column 37, (2013/04/13)

This disclosure relates to compounds, compositions and methods for the treatment of various disorders. In particular, the disclosure relates to thiazolotriazole and thiazoloimidazole compounds which agonize the activity of the protein TGR5. Formula (I)

REGULATION OF PROTEIN SYNTHESIS

-

Page/Page column 41, (2010/06/19)

A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 137506-14-0